离心训练对2型糖尿病人群干预作用的研究

发布时间：2018-06-25 01:51

本文选题：离心训练 + 骨骼肌细胞外基质　；参考：《曲阜师范大学》2017年硕士论文

【摘要】：1目的:2型糖尿病是最常见的非传染性慢性疾病,被认为是一种运动缺乏的疾病。运动作为预防或治疗2型糖尿病的较好手段,在促进身体健康、降低糖尿病发病率的过程中起着积极作用。目前,2型糖尿病的运动干预手段有三种形式,即耐力训练、抗阻力训练以及耐力-抗阻力混合训练,其中任何一种训练方式均具有疗效,部分学者认为离心抗阻力训练优越于其他运动形式。本研究采用离心抗阻力训练模式,旨在研究离心训练治疗2型糖尿病患者的疗效问题。2方法:选取26名2型糖尿病患者作为研究对象,随机分为对照组与离心抗阻力训练组。离心抗阻力训练组训练8周,每周3次,训练方案:1-2周为12RM、离心收缩对抗10s;3-4周为12RM、离心收缩对抗12s;5-6周为12RM、离心收缩对抗15s;7-8周为12RM、离心收缩对抗17s。对照组与离心抗阻力训练组在训练前1周和末次训练后隔日清晨采集肘正中静脉血样,检测血常规(白细胞、中性粒细胞、淋巴细胞和血小板计数)、空腹血糖、胰岛素、糖化血红蛋白、甘油三脂、总胆固醇、高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇、基质金属蛋白酶-2、基质金属蛋白酶-9、羟脯氨酸和肌酸激酶浓度变化。3结果:3.1与健康受试者相比,2型糖尿病患者临床参数具体变化是:(1)空腹血糖、胰岛素、和糖化血红蛋白呈极显著性升高(P0.001),甘油三脂、总胆固醇、高密度脂蛋白-胆固醇及胰岛素抵抗指数呈显著性升高(P0.05,P0.001);(2)白细胞计数呈非常显著性增加(P0.01),中性粒细胞计数以及中性粒细胞计数与淋巴细胞计数比率呈显著性增加(P0.05);(3)基质金属蛋白酶2和9浓度呈非常显著性升高(分别为P0.01、P0.001)。3.2离心抗阻力训练组与对照组2型糖尿病受试者代谢相关指标组内变化分别为:与10周前相比,(1)离心抗阻力训练组2型糖尿病受试者空腹血糖、胰岛素浓度呈显著性降低(P0.05),胰岛素抵抗指数呈非常显著性降低(P0.01),糖化血红蛋白值呈极显著性降低(P0.001);(2)2型糖尿病对照组受试者空腹血糖、胰岛素、糖化血红蛋白以及胰岛素抵抗指数均无显著性变化(P0.05)。离心抗阻力训练组与对照组2型糖尿病受试者代谢相关指标组间变化为:与对照组2型糖尿病受试者相比,离心抗阻力训练组空腹血糖呈现显著下降的趋势(P=0.07),胰岛素浓度、糖化血红蛋白值和胰岛素抵抗指数均无显著性变化(P0.05),但胰岛素浓度、糖化血红蛋白值和胰岛素抵抗指数分别下降37%、7%和39%。3.3离心抗阻力训练组与对照组2型糖尿病受试者基质金属蛋白酶2和9和羟脯氨酸浓度组内变化分别为:与10周前相比,(1)离心抗阻力训练组2型糖尿病受试者血清中基质金属蛋白酶2浓度呈显著性降低(P0.05),基质金属蛋白酶9浓度呈显著性升高(P0.05),羟脯氨酸浓度呈非常显著性升高(P0.01);(2)2型糖尿病对照组受试者血清基质金属蛋白酶2浓度非常显著性降低(P0.05),基质金属蛋白酶9和羟脯氨酸浓度无显著性变化(P0.05)。离心抗阻力训练组与对照组2型糖尿病受试者基质金属蛋白酶2和9和羟脯氨酸浓度组间变化为:与对照组2型糖尿病受试者相比,离心抗阻力训练组血清中基质金属蛋白酶2的浓度呈显著性降低(P0.05),基质金属蛋白酶9浓度呈非常显著性升高(P0.01),羟脯氨酸浓度呈极显著性升高(P0.001)。4结论:4.1离心抗阻力训练可以降低2型糖尿病患者的空腹血糖、胰岛素、Hb A1c和胰岛素抵抗指数,提高胰岛素敏感性。4.2离心抗阻力训练下调了血液中基质金属蛋白酶-2浓度,增加了基质金属蛋白酶-9浓度。4.3离心抗阻力训练可以改善2型糖尿病症状,与基质金属蛋白酶浓度变化有关。
[Abstract]:1 Objective: type 2 diabetes is the most common non communicable chronic disease, which is considered to be a lack of exercise. Exercise is a good means to prevent or treat type 2 diabetes. It plays an active role in promoting health and reducing the incidence of diabetes. At present, there are three forms of exercise intervention for type 2 diabetes, that is, resistance to diabetes. Force training, resistance training and endurance resistance mixed training, of which any one of the training methods are effective, some scholars believe that centrifugal resistance training is superior to other forms of exercise. In this study, centrifugal resistance training model was used to study the effect of centrifugal training in the treatment of type 2 diabetes patients.2 method: 26 The patients with type 2 diabetes were randomly divided into the control group and the centrifugal resistance training group. The centrifuge resistance training group was trained for 8 weeks, 3 times a week, the training program was 12RM, the centrifugal contraction against 10s, the 3-4 week 12RM, the centrifugal contraction against 12s, the 5-6 week 12RM, the centrifugal contraction against 15s, the 7-8 week 12RM, and the centrifugal contractions against 17s. control. The group and the centrifugal resistance training group collected the median vein blood samples of the elbow in the early morning 1 weeks before and after the last training, and tested the blood routine (leukocyte, neutrophils, lymphocyte and platelet count), fasting blood glucose, insulin, glycated hemoglobin, glycerol three fat, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein - gallbladder. Sterol, matrix metalloproteinase -2, matrix metalloproteinase -9, hydroxyproline and creatine kinase concentration changes.3 results: 3.1 compared with healthy subjects, the specific changes in clinical parameters of patients with type 2 diabetes were: (1) hyperglycemia, insulin, and glycated hemoglobin were significantly elevated (P0.001), glycerol three fat, total cholesterol, high density lipoprotein The index of cholesterol and insulin resistance increased significantly (P0.05, P0.001); (2) the white cell count increased significantly (P0.01), neutrophils count, neutrophils count and lymphocyte count ratio increased significantly (P0.05), (3) the concentration of matrix metalloproteinase 2 and 9 increased significantly (P0.01, P0.001, respectively) .3.2 centrifuge resistance training group and the control group of type 2 diabetic subjects were compared with those in the control group: compared with 10 weeks ago, (1) the concentration of insulin was significantly decreased (P0.05), the insulin resistance index was significantly decreased (P0.01), and the glycated hemoglobin value was significantly reduced. There was a very significant decrease (P0.001); (2) there was no significant change in fasting blood glucose, insulin, glycosylated hemoglobin and insulin resistance index in the control group of type 2 diabetes mellitus. The changes in metabolic related indexes between the centrifugal resistance training group and the control group of type 2 diabetic subjects were compared with those in the control group of type 2 diabetic subjects. There was a significant decrease in fasting blood glucose in the anti resistance training group (P=0.07), insulin concentration, glycosylated hemoglobin value and insulin resistance index had no significant changes (P0.05), but insulin concentration, glycosylated hemoglobin value and insulin resistance index decreased by 37%, 7% and 39%.3.3 centrifuge resistance training group and control group 2 type diabetes. The changes of matrix metalloproteinase 2 and 9 and hydroxyproline concentration in the subjects were as follows: compared with 10 weeks ago, (1) the concentration of matrix metalloproteinase 2 in the serum of type 2 diabetic subjects was significantly decreased (P0.05), the concentration of matrix metalloproteinase 9 was significantly increased (P0.05), and the concentration of hydroxyproline was very significant. The concentration of matrix metalloproteinase 2 was significantly decreased (P0.05) and the concentration of matrix metalloproteinase 9 and hydroxyproline was not significantly changed (P0.05) in the subjects of type 2 diabetes control group (2). The concentration of matrix metalloproteinase 2 and 9 and hydroxyproline in the control group and the control group of type 2 diabetic subjects were significantly different from those in the control group. Compared with the control group of type 2 diabetes, the concentration of matrix metalloproteinase 2 in serum of centrifugal resistance training group decreased significantly (P0.05), the concentration of matrix metalloproteinase 9 increased significantly (P0.01), the concentration of hydroxyproline was significantly increased (P0.001).4 conclusion: 4.1 centrifuge resistance training can reduce the type of sugar 2 Fasting blood glucose, insulin, Hb A1c and insulin resistance index in patients with urinary disease, increasing insulin sensitivity.4.2 centrifugal resistance training down regulated the concentration of matrix metalloproteinase -2 in the blood, and increased the concentration of matrix metalloproteinase -9 in.4.3 centrifugal resistance training to improve the symptoms of type 2 diabetes, and the change of matrix metalloproteinase concentration Of
【学位授予单位】：曲阜师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1;G808.1

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