内质网-线粒体结构偶联及运动应激研究进展

发布时间：2018-10-25 15:36

【摘要】：诸多生命活动依赖于线粒体和内质网的协作。MAMs是存在于线粒体和内质网间,由蛋白质复合体组成的特殊结构,其结构的完整性和生理功能的正常运行是保证线粒体动态变化、细胞凋亡和内质网应激等生命过程有序进行的前提。对MAMs的最新研究动态进行归纳,提出Ca~(2+)在MAMs调控中的决定性作用,MAMs在ROS、内质网应激、细胞凋亡、细胞自噬、线粒体动态变化及流动性和炎症等过程中扮演的重要角色,探讨运动应激对MAMs的可能调节机制及MAMs相关分子介导运动适应的途径,从而为未来运动适应机制的探索提供新的研究方向。
[Abstract]:Many life activities depend on the cooperation of mitochondria and endoplasmic reticulum. MAMs is a special structure composed of protein complex, which exists between mitochondria and endoplasmic reticulum. The integrity of structure and the normal functioning of physiological function ensure the dynamic changes of mitochondria. Apoptosis and endoplasmic reticulum stress are prerequisites for orderly progression of life processes. This paper summarizes the latest research trends of MAMs, and points out the decisive role of Ca~ (2) in the regulation of MAMs. MAMs plays an important role in ROS, endoplasmic reticulum stress, apoptosis, autophagy, dynamic changes of mitochondria, fluidity and inflammation. To explore the possible regulatory mechanism of exercise stress on MAMs and the pathway of MAMs related molecules mediating motor adaptation, thus providing a new research direction for the exploration of sports adaptation mechanism in the future.
【作者单位】：华东师范大学青少年健康评价与运动干预教育部重点实验室;华东师范大学体育与健康学院;
【基金】：国家自然科学基金资助项目(31600967) 青少年健康评价与运动干预教育部重点实验室建设项目(40500-541235-14203/004)
【分类号】：G804.7

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