维生素D对骨骼肌健康的影响及其机制的研究进展

发布时间：2018-11-22 13:03

【摘要】：维生素D是20世纪初发现的一种脂溶性维生素,其经典作用是调节钙、磷代谢维持骨健康。近年,随着骨骼肌细胞中维生素D受体的发现,维生素D对骨骼肌健康的作用成为新的研究热点。研究认为,维生素D通过基因机制和非基因机制发挥作用。观察性研究发现,无论是普通人群还是运动员,其维生素D浓度与骨骼肌健康程度有关;但维持骨骼肌健康的最佳血清25(OH)D浓度还未确定。随机对照试验研究关于维生素D补充对骨骼肌形态、骨骼肌运动表现等的作用尚无定论,上肢和下肢不同肌群对维生素D补充的适应性反应存在差异,可能与维生素D受体浓度和基因多态性有关。此外,维生素D可能通过增加内源性睾酮,而具有增进身体机能的潜在作用,这在体育领域具有重要意义,但其机制还有待深入探讨。
[Abstract]:Vitamin D is a kind of fat-soluble vitamin discovered in the early 20th century. Its classical function is to regulate calcium and phosphorus metabolism to maintain bone health. In recent years, with the discovery of vitamin D receptor in skeletal muscle cells, the effect of vitamin D on skeletal muscle health has become a new research hotspot. Studies suggest that vitamin D works through both genetic and non-genetic mechanisms. Observational studies showed that vitamin D concentrations in both the general population and athletes were related to skeletal muscle health, but the best serum 25 (OH) D concentration for maintaining skeletal muscle health had not been determined. The effects of vitamin D supplementation on skeletal muscle morphology and skeletal muscle motor performance were inconclusive in randomized controlled trials. The adaptive responses of different muscle groups of upper and lower limbs to vitamin D supplementation were different. It may be associated with vitamin D receptor concentration and gene polymorphism. In addition, vitamin D may play a potential role in enhancing body function by increasing endogenous testosterone, which is of great significance in the field of physical education, but its mechanism remains to be further explored.
【作者单位】：上海体育学院运动科学学院;商丘师范学院体育学院;
【基金】：国家自然科学基金资助项目(31571226) 上海高校特聘教授东方学者项目(TP2014057)
【分类号】：G804.2

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