四周少量CO吸入模拟高原训练对有氧能力的影响

发布时间：2018-11-24 12:34

【摘要】：研究目的:通过研究吸入一氧化碳后,体内碳氧血红蛋白含量和促红细胞生成素的变化,以及长期吸入一氧化碳后进行训练对受试者有氧能力的影响,探讨吸入一氧化碳结合运动训练对人体红细胞生成、心肺功能以及肌肉组织利用氧能力的作用。初步判断通过一氧化碳创造体内低氧环境,进行低氧训练的有效性,为更加高效经济地进行低氧训练提供一种新的训练思路及方法。研究方法:以12名北京体育大学男性学生为研究对象,先让所有受试者在安静状态下吸入适量一氧化碳(CO,1ml/kg体重),检测吸入一氧化碳前、第1、2、4、6、8小时呼气中的一氧化碳浓度、指血碳氧血红蛋白浓度、及血清促红细胞生成素的含量。根据最大摄氧量的大小排序,先两两分组,再随机分配到实验组和对照组。之后进行为期4周,每周3次的有氧训练,每次40分钟,训练速度为通气无氧阈90%对应的速度。要求实验组受试者在训练前吸入适量一氧化碳和氧气,对照组只吸入氧气。在4周训练前后,用渐增负荷的运动测试测最大摄氧量,用改良一氧化碳吸入法测血红蛋白总量及其他相关血液指标。研究结果:(1)吸入CO后,指血HBCO%从0.7迅速显著升高到5.81(p0.05),然后随时间逐渐下降,8小时后降低到1.48,仍显著高于基础值;(2)吸入CO后,血清EPO浓度在2小时后显著升高(p0.05),从1.912 mIU/mL提高到2.427 mIU/mL,升高幅度为26.9%,4小时后到达峰值2.720mIU/mL,升高幅度为42.3%,之后随时间逐渐下降;(3)4周训练结束后实验组血红蛋白总量(tHb)显著升高(p0.05),从918.5g提高到972.5g,升高幅度为5.9%,对照组无显著变化;(4)4周训练结束后实验组最大摄氧量(VO2max)显著升高(p0.05),从4.78 l/min提高到5.10 l/min,提高幅度为6.7%,对照组无显著性差异;(5)4周训练后实验组和对照组在次最大强度下跑步时的摄氧量均显著下降(p0.05),实验组下降的幅度更大,在速度为8km/h、10 km/h、12 km/h时的下降幅度分别为,实验组25.7%、23.9%、16.8%,对照组17.6%、16.2%、16.2%。研究结论:按照1ml/kg体重的剂量吸入CO,可以使人体促红细胞生成素(EPO)的分泌增加,峰值出现在4小时左右;CO模拟高原训练可以增加血红蛋白总量,提高最大摄氧量并降低在较低速度跑步时的能量消耗。
[Abstract]:Objective: to study the changes of carboxyhemoglobin and erythropoietin after inhalation of carbon monoxide and the effects of long-term training on aerobic capacity of subjects after inhalation of carbon monoxide. To investigate the effects of inhaled carbon monoxide (CO) combined with exercise training on erythropoiesis, cardiopulmonary function and the ability of muscle tissue to utilize oxygen. It is preliminarily judged that the hypoxic environment can be created by carbon monoxide, and the effectiveness of hypoxic training can be provided as a new train of thought and method for more efficient and economical hypoxic training. Methods: twelve male students of Beijing University of physical Education were asked to inhale proper amount of carbon monoxide (CO,1ml/kg) in a quiet state. Carbon monoxide concentration, blood carbon-oxyhemoglobin, and serum erythropoietin in 8 hours breath. According to the order of maximal oxygen intake, two groups were divided into two groups, then randomly assigned to the experimental group and the control group. Then the aerobic training was conducted for 4 weeks three times a week for 40 minutes each time and the training speed was 90% of the ventilation anaerobic threshold. Subjects in the experimental group were asked to inhale proper amount of carbon monoxide and oxygen before training, while the control group only inhaled oxygen. Before and after 4 weeks of training, the maximal oxygen uptake was measured by incremental exercise test, and the total hemoglobin and other related blood indexes were measured by modified carbon monoxide inhalation method. The results were as follows: (1) after inhaling CO, the HBCO% of finger blood increased rapidly from 0.7 to 5.81 (p0.05), then decreased gradually with time, and decreased to 1.48 after 8 hours, which was still significantly higher than the base value; (2) after inhalation of CO, the concentration of serum EPO increased significantly after 2 hours (p0.05), and increased from 1.912 mIU/mL to 2.427 mIU/mL, by a peak value of 2.720mIUmL after 4 hours. The increase was 42.3%, and then decreased gradually with time. (3) after 4 weeks of training, the total hemoglobin (tHb) of the experimental group increased significantly (p0.05), from 918.5 g to 972.5 g, and the increase was 5.9, while the control group had no significant change. (4) the maximal oxygen uptake (VO2max) in the experimental group increased significantly from 4.78 l/min to 5.10 L / min after 4-week training, and the increase was 6.7 L / min, but there was no significant difference in the control group. (5) after 4 weeks of training, the oxygen uptake of both the experimental group and the control group decreased significantly under the second maximum intensity (p0.05), and the decrease in the experimental group was even greater, at a speed of 8 km / h ~ (10 km/h,). The decrease at 12 km/h in the experimental group was 25. 7 and 23. 9% and 16. 8, respectively. The control group was 17. 6% and 16. 2%, and the control group was 16. 2%. Conclusion: according to the dose of 1ml/kg, inhaling CO, can increase the secretion of human erythropoietin (EPO), and the peak value is about 4 hours. CO simulated altitude training can increase the total amount of hemoglobin, increase the maximal oxygen uptake and reduce the energy consumption during running at a lower speed.
【学位授予单位】：北京体育大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：G804.2

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