探究式教学在基因组学课程中的实例研究:基于比较基因组学鉴定大肠杆菌致病因子

发布时间：2018-05-25 00:27

本文选题：探究式教学 + 基因组学　；参考：《遗传》2015年02期

【摘要】：基因组学是现代生命科学中众多"组学"研究方法的核心,越来越受到高校生物教学的重视,但目前关于其教学方法的研究报道较少。文章以大肠杆菌致病因子的比较基因组学教学作为一个专题教学实例,展示探究式教学法在基因组学课程中的应用。学生首先以Mauve软件比较不同大肠杆菌的基因组,分析基因的保守性,并以BLAST检索基因的功能注释信息,从而鉴定其是否为致病因子基因。在该专题教学中,整个教学过程通过情境、资源、任务、过程、评价5个模块来组织实施。教学效果表明,通过探究式教学的应用,学生在掌握基因组学课程知识与专业技能的基础上,提高了科研兴趣与自主学习能力。此外,该专题教学内容还可应用于其他相关课程如微生物学、生物信息学、分子生物学及食品安全检测技术等。
[Abstract]:Genomics is the core of many "group" research methods in modern life science, and has been paid more and more attention to in college biology teaching. However, there are few reports on its teaching methods at present. Taking the comparative genomics teaching of pathogenic factors of Escherichia coli as an example, this paper demonstrates the application of inquiry teaching method in the course of genomics. First, the genomes of different Escherichia coli were compared with Mauve software, and the conserved genes were analyzed, and the functional annotation information of genes was retrieved by BLAST to identify whether they were pathogenic genes. In this project teaching, the whole teaching process is organized and implemented through five modules: situation, resource, task, process and evaluation. The teaching effect shows that through the application of inquiry teaching, students can improve their scientific research interest and autonomous learning ability on the basis of mastering the knowledge and professional skills of genomics course. In addition, the course can also be applied to other related courses such as microbiology, bioinformatics, molecular biology and food safety detection techniques.
【作者单位】：浙江育英职业技术学院生物技术系;浙江工商大学食品与生物工程学院;
【基金】：浙江省教育科学规划研究课题(编号:SCG348) 国家自然科学基金青年项目(编号:31101339)资助
【分类号】：Q75-4;G712

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