基于DMAIC方法的企业生产成本控制研究

发布时间：2018-06-27 10:28

本文选题：TOC + DMAIC流程　；参考：《天津科技大学》2015年硕士论文

【摘要】：中国制药产业市场化至今已有三十多个年头,伴随着中国改革开放以来我国快速的经济发展,制药产业市场化也达到了较高的程度,已经具备了一定的克服困难、解决问题的能力。最近几年,国家出台了一系列的政策、法律、法规和标准,对医药行业政策和监管政策进行规范和调整,任何一次调控都会对医药行业或相关药品产业链上的利益格局造成一定程度的影响,会促进一些企业快速发展而部分企业就要面对政策调控所带来的压力与风险。随着国家出台抗生素药品降价和限用等一系列政策,抗生素产业链条上的生产企业毫无疑问要面临巨大的生存压力和遇到前所未有的经营困难,面对限制抗生素政策与规范,以及基本药物招标价格持续走低,随着基本药物边缘品种空间的缩小,要想在基本药物外围追寻市场机会也变得越来越困难。基药目录下的药品必须要进行基药招标,药品企业必须要以低的药品价格来换取销售量。因此,天津医药集团津康制药有限公司想要立足医药市场,必须调整产品结构、提高自身优势；必须在提品质、增收率、控成本、降能耗上下功夫,增加企业产品的市场竞争力。本文以公司头孢类药物链条上几个点为例,进行提高产品质量和收率等问题的研究。本文以天津医药集团津康制药有限公司GCLE原料药中间体为研究对象,运用基于TOC理念的DMAIC流程,对影响GCLE原料药成本的因素进行分析,通过研究寻求控制GCLE原料药成本的方法,达到降低成本的目的。本文首先对GCLE生产情况进行调查分析,找到影响产品成本的若干要素,找出主要因素；第二,量化其影响产品质量和收率的各项指标,利用EXCEL建立回归模型,通过分析确定合理的技术参数,在此技术参数条件下生产的产品质量与收率得到提高,从而达到降低生产成本的目标；第三,坚持PDCA的原则,分析出影响产品质量的新问题,再对其进行研究,最终确定的技术参数可以使GCLE原料药的质量和原料成本得到优化,达到成本控制的目的。通过本文的研究成果,可为企业节约一定的生产成本,研究方法可对企业内部起到一些借鉴作用,从一定程度上促进企业的管理水平更加科学和合理。
[Abstract]:China's pharmaceutical industry has been market-oriented for more than 30 years. With the rapid economic development of China since the reform and opening up, the pharmaceutical industry has also reached a relatively high level of marketization, and has already had certain difficulties to overcome. Ability to solve problems. In recent years, the state has issued a series of policies, laws, regulations and standards to standardize and adjust the policies and regulatory policies of the pharmaceutical industry. Any regulation and control will have a certain degree of influence on the benefit pattern of the pharmaceutical industry or related pharmaceutical industry chain. It will promote the rapid development of some enterprises and some enterprises will face the pressure and risk brought by the policy regulation. With the introduction of a series of policies such as lowering the price and restricting the use of antibiotics, there is no doubt that the production enterprises in the antibiotic industry chain will face enormous survival pressure and unprecedented operational difficulties, and face the restrictions on antibiotic policies and regulations. As the bidding price of essential drugs continues to decline, it is becoming more and more difficult to pursue market opportunities in the periphery of essential drugs as the margin of essential drugs becomes smaller. Drugs listed in the list of basic drugs must be subject to bidding, and drug companies must exchange low drug prices for sales. Therefore, in order to base itself on the pharmaceutical market, Tianjin Pharmaceutical Group Jinkang Pharmaceutical Co., Ltd. must adjust its product structure and improve its own advantages. It must work hard to raise quality, increase income rate, control costs, and reduce energy consumption. Increase the market competitiveness of enterprise products. In this paper, we take several points on the chain of cephalosporins as examples to study the improvement of product quality and yield. Based on the DMAIC process based on TOC, this paper analyzes the factors that affect the cost of GCLE API, and finds out the method to control the cost of GCLE API by studying the GCLE API intermediate of Tianjin Pharmaceutical Group Jinkang Pharmaceutical Co., Ltd. Achieve the goal of reducing costs. In this paper, the production of GCLE is investigated and analyzed, and some factors affecting the product cost are found out. Secondly, the indexes affecting the product quality and yield are quantified, and the regression model is established by excel. Through the analysis and determination of reasonable technical parameters, the product quality and yield are improved under the condition of these technical parameters, so as to achieve the goal of reducing the production cost. Thirdly, adhere to the principle of PDCA, analyze the new problems that affect the product quality. The final technical parameters can optimize the quality and raw material cost of GCLE API and achieve the purpose of cost control. The research results of this paper can save a certain production cost for the enterprise, the research method can play some reference role to the enterprise interior, and promote the management level of the enterprise to a certain extent more scientific and reasonable.
【学位授予单位】：天津科技大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：F406.72;F426.72

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