磁性纳米二氧化硅的制备与性能研究

发布时间：2018-01-28 12:14

本文关键词： 二氧化硅四氧化三铁纳米荧光　出处：《长春理工大学学报(自然科学版)》2016年06期 　论文类型：期刊论文

【摘要】：纳米二氧化硅(nSiO_2)微球因其比表面积大、表面吸附力强、其表面富含可供改性的化学官能团,并且稳定性高,目前已经广泛用于模板化包药、药物运载、药物缓释等领域。以磁性Fe_3O_4为核,采用共沉淀法制备出有核壳结构的磁性纳米二氧化硅(nMSiO_2)微球,在药物传输以及荧光标记诊断方面可以实现磁导向,具有潜在的应用价值。在nMSiO2微球上接枝可以发荧光的异硫氰酸(FITC),可以实现磁引导的同时示踪。获得的nMSiO_2微球利用磁性测试、X射线衍射(XRD)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和红外光谱(FTIR)进行结构和性能的表征,结果表明,nSiO_2微球包裹了磁性Fe_3O_4后,nMSiO_2微球具备磁性,且其性能与纯nSiO_2有了本质的差异,接枝异硫氰酸且能够发出荧光。
[Abstract]:Nano-silica nSiO2) microspheres have been widely used in templating because of their large surface area, strong surface adsorption, rich chemical functional groups for modification and high stability. In the field of drug delivery and drug delivery, magnetic nanocrystalline silica nMSiO2 microspheres with core-shell structure were prepared by co-precipitation method using magnetic Fe_3O_4 as core. It has potential application value in drug delivery and fluorescent labeling diagnosis. It can be grafted on nMSiO2 microspheres to produce fluorescent isothiocyanate (FITC). The obtained nMSiO_2 microspheres were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Transmission electron microscopy (TEM) and infrared spectroscopy (FTIR) were used to characterize the structure and properties of the microspheres. The results showed that the microspheres were encapsulated with magnetic Fe_3O_4. NMSiO_2 microspheres have magnetic properties, and their properties are essentially different from those of pure nSiO_2. The nMSiO_2 microspheres are grafted with isothiocyanate and can emit fluorescence.
【作者单位】：长春理工大学材料科学与工程学院;北京市顺义区第一中学;
【基金】：中国博士后科学基金资助项目(2014M561268)
【分类号】：TQ127.2;TB383.1
【正文快照】： 纳米二氧化硅(n Si O2)微球是一种粒子直径为纳米尺度的球形材料,近年来在药物载体和控制释放得到了广泛的研究和应用[1,2]。通过吸入,经皮渗透或者注射等途径可将n Si O2微球引入生物体。其中,经肺吸入的方式能使n Si O2微球载药体系越过“血肺屏障”直接进入血液循环,进而实

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