磁性功能材料在药物负载及分析中的应用研究

发布时间：2018-04-17 13:17

本文选题：功能化磁性纳米材料 + 吸附　；参考：《沈阳理工大学》2015年硕士论文

【摘要】：氧化石墨烯和碳纳米管具有易功能化修饰,比表面积大等优点。可以有效的对药物进行吸附、负载并进行靶向运输,可以用在药物主要成分的分析、抗癌药物的负载和药缓释等方面。本论文致力于将氧化石墨烯和碳纳米管进行功能化修饰,制备具有良好吸附性能的磁性纳米材料,并考察其药物负载及分析性能。(1)通过Hummers法制备氧化石墨烯(GO),水热法制备氨基化四氧化三铁(NH2-Fe3O4),通过对GO的功能化修饰制备出氨基化四氧化三铁氧化石墨烯磁性纳米材料(NH2-Fe3O4/GO)。并使用SEM、XRD、FT-IR和VSM对其形貌,结构等进行分析,并考察了NH2-Fe3O4/GO对四环素的吸附性能。结果表明在p H=5.0,吸附时间为75min,NH2-Fe3O4/GO加入量为6.0mg时,吸附容量为31mg/g,吸附率在95%以上,且低温更有利于提高吸附效果。使用浓度为0.30mol/L的硼酸钠溶液作为洗脱液,洗脱率达到96%以上,并用于实际样品中四环素的分析。(2)将盐酸多巴胺修饰在NH2-Fe3O4/GO表面,制备氨基化四氧化三铁氧化石墨烯@多巴胺(NH2-Fe3O4/GO@PDA)功能材料。使用SEM、XRD、FT-IR和VSM等表征手段对所制备的材料进行表征,并考察了NH2-Fe3O4/GO@PDA对环丙沙星的吸附性能。结果表明,最佳吸附条件为:p H为7.0,吸附时间为70min,吸附剂用量为3.0mg时,吸附容量为43.48mg/g。使用0.6mol/L盐酸为洗脱液,洗脱率大于96%,并将所制备的NH2-Fe3O4/GO@PDA用于实际样品中环丙沙星含量的分析。(3)采用水热法制备出磁多壁碳纳米管(m-MWCNTs),并用盐酸多巴胺将其功能化修饰,制备出磁多壁碳纳米管@盐酸多巴胺(m-MWCNTs@PDA)磁性功能材料。并使用各种表征手段对其形貌,结构进行分析,所制备的材料表面光滑,粒径分布均匀并且具有超顺磁性,考察m-MWCNTs@PDA对槲皮素的负载性能,在最佳负载条件下,负载容量为36.63mg/g,负载率可达到94%以上。使用0.20mol/L的氢氧化钠溶液作为洗脱液,洗脱率高于98%,m-MWCNTs@PDA-槲皮素载药体系可以持续释放药物15h以上。
[Abstract]:Graphene oxide and carbon nanotubes with easy functionalization, large surface area etc.. Can effectively adsorb drug load and targeted transport, analysis can be used in the main components of drugs, anticancer drugs and drug load and so on. This paper is devoted to the graphene oxide and carbon nanotubes the function of modified magnetic nano material preparation has good adsorption properties, and investigate the drug load and performance analysis. (1) the preparation of graphene oxide by Hummers method (GO), hydrothermal synthesis of amino functionalized Fe3O4 (NH2-Fe3O4), through the modification of GO prepared by amination of Fe3O4 oxide graphene nano magnetic material (NH2-Fe3O4/GO). And the use of SEM, XRD, FT-IR and VSM on the morphology, structure analysis, and the effects of NH2-Fe3O4/GO on the adsorption of tetracycline. The results show that in P H=5.0, adsorption time For 75min, the addition amount of NH2-Fe3O4/GO is 6.0mg, the adsorption capacity of 31mg/g, the adsorption rate was above 95%, and low temperature is beneficial to the improvement of adsorption effect. The use of concentration of sodium borate solution 0.30mol/L as the eluent, elution rate reached more than 96%, and for the analysis of tetracycline in real samples. (2) will be modified in dopamine hydrochloride the surface of NH2-Fe3O4/GO, preparation of aminated graphene oxide Fe3O4 @ dopamine (NH2-Fe3O4/GO@PDA) functional materials. The use of SEM, XRD, of the prepared materials were characterized by FT-IR and VSM techniques, and the effects of NH2-Fe3O4/GO@PDA on adsorption of ciprofloxacin. The results showed that the optimum adsorption conditions were as follows: P H was 7, adsorption time 70min, adsorbent dosage was 3.0mg, the adsorption capacity of 43.48mg/g. using 0.6mol/L hydrochloric acid as eluent, elution rate greater than 96%, and the NH2-Fe3O4/GO@PDA prepared for actual samples in Analysis of ciprofloxacin content. (3) prepared by hydrothermal method magnetic multi walled carbon nanotubes (m-MWCNTs), and its modification with dopamine hydrochloride, preparation of magnetic MWNTs @ dopamine hydrochloride (m-MWCNTs@PDA) magnetic functional material. And use the various characterization methods on the morphology, structure analysis the surface preparation materials, smooth, uniform particle size distribution and superparamagnetism, load performance of m-MWCNTs@PDA was investigated in quercetin, optimum load condition, the load capacity of 36.63mg/g, the load rate can reach more than 94%. The use of 0.20mol/L sodium hydroxide solution as the eluent, elution rate is higher than 98% m-MWCNTs@PDA-, quercetin as drug delivery system can sustained release drug 15h.

【学位授予单位】：沈阳理工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB34;TQ460.1

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