还原态氧化钼的制备与光热应用

发布时间：2018-03-28 12:19

本文选题：MoO_(3-x)量子点　切入点：界面水蒸发　出处：《哈尔滨工业大学》2017年硕士论文

【摘要】：氧化钼是重要的过渡金属氧化物,在传感器、催化剂、电致变色、光致变色、锂离子电池、太阳能电池等许多方面都具有潜在的应用价值。而非化学计量比的氧化钼在可见-近红外区具有可调的光学吸收,是一种很好的光热材料。本文利用水热法合成出氧缺陷MoO_(3-x)量子点,通过理论模拟研究了MoO3-x量子点特殊的光学性能,并将其用于界面水蒸发和光声成像引导的肿瘤光热与光动力协同治疗。具体的研究内容如下:本文采用水热法,通过改变壳聚糖的量、反应温度和Mo元素的浓度,获得多种形貌的氧化钼纳米材料,通过透射电子显微镜、X-射线衍射能谱和紫外-可见-近红外吸收光谱进行表征,最终选择在可见-近红外区吸收较高的还原态氧化钼量子点作为光热材料,并利用X-射线光电子能谱、电子顺磁共振分析、拉曼光谱证明了MoO3-x量子点存在氧缺陷。理论模拟证明了MoO_(3-x)量子点在可见-近红外区的强吸收是由氧缺陷引起。另外,MoO_(3-x)量子点的紫外-可见-近红外吸收光谱与太阳光谱相匹配。论文利用MoO_(3-x)量子点的光热性能制备了MoO_(3-x)量子点膜用于界面水蒸发实验,研究结果表明MoO_(3-x)量子点膜有极好的界面热效果,在光照射下实现高效的界面水蒸发效果。本论文通过单一物种MoO_(3-x)量子点实现了光声成像引导的光热与光动力协同治疗,基于MoO_(3-x)量子点强的近红外光吸收能力,能够将近红外光转换成局部高热,同时产生单线态氧。因此,可以作为有效的光热剂和光敏剂,并在细胞实验和动物实验中证实其优异的抗肿瘤特性。MTT实验表明MoO_(3-x)量子点没有明显的毒性。在进一步的研究中,MoO_(3-x)量子点被用来消除He La荷瘤裸鼠的肿瘤,组织学检测表明小鼠的主要脏器没有明显的损伤,MoO_(3-x)量子点主要是通过肝脏和脾脏代谢掉的。此外,基于理想的光热效果,MoO_(3-x)量子点也能被作为外源的光声造影剂用于活体成像来描述肿瘤。综上所述,本论文合成的MoO_(3-x)量子点在可见和近红外区有较高的吸收,吸收光谱与太阳光谱相匹配,能产生很好的界面热效果,而且MoO_(3-x)量子点单一物种作为多功能诊疗剂,避免了复合物体系中各组分之间互相干扰和容易泄露的缺点。
[Abstract]:Molybdenum oxide is transition metal oxides, important in catalysts, sensors, electrochromic, photochromic, lithium ion batteries, which have a potential application in many aspects such as solar battery. And non stoichiometric molybdenum oxide with adjustable light in the visible and near infrared absorption studies, is a very good thermal material. In this paper, the synthesis of oxygen deficient MoO_ by hydrothermal method (3-x) quantum dots, through theoretical simulation on the optical properties of MoO3-x quantum dots, and the interface for the water evaporation and photoacoustic imaging guided tumor photothermal and photodynamic CO treatment. The specific contents are as follows: This paper uses water thermal method, by changing the amount of chitosan concentration, reaction temperature and Mo elements, obtain molybdenum oxide nano materials with various morphologies, through transmission electron microscope, X- ray diffraction spectroscopy and UV Vis NIR absorption spectra were characterized, The final choice in the reduced state of molybdenum oxide quantum dots visible and near infrared absorption high as thermal material, and using X- ray photoelectron spectroscopy, electron paramagnetic resonance, Raman spectroscopy has proved the existence of oxygen defects in MoO3-x quantum dots. The theoretical simulation proved that MoO_ (3-x) quantum dots in the visible and near infrared region strong the absorption is caused by oxygen deficiency. In addition, MoO_ (3-x) - quantum dots UV visible near infrared absorption spectrum and the solar spectral matching. The paper uses MoO_ (3-x) MoO_ were prepared for thermal properties of quantum dots (3-x) quantum dots film interface for water evaporation experiment, the results show that the MoO_ (3-x) quantum dots film has excellent thermal interface effect, achieve efficient interfacial water evaporation effect under visible light irradiation. The single species MoO_ (3-x) quantum dots for photothermal and photoacoustic imaging guided photodynamic therapy based on collaborative, MoO_ (3-x) quantum dots strong near Infrared absorption ability to near infrared is converted into local hyperthermia, and produce singlet oxygen. Therefore, can be used as an effective photothermal agent and a photosensitizer, and in cell and animal experiments confirmed the excellent antitumor properties of.MTT assay showed that MoO_ (3-x) quantum dots have no obvious toxicity. In further research, MoO_ (3-x) quantum dots is used to remove He La nude mice tumor, histological examination showed no obvious damage to the main organs of mice, MoO_ (3-x) quantum dots is mainly through the liver and spleen metabolize. In addition, the ideal photothermal effect based on MoO_ (3-x), quantum dots can also be used as photoacoustic contrast agent for in vivo imaging to describe the exogenous tumor. In summary, the synthesis of MoO_ (3-x) has a high absorption in the visible and near infrared region of the quantum dots, the absorption spectrum and the solar spectral matching, can produce good The interface thermal effect, and MoO_ (3-x) quantum dot single species as a multifunctional diagnostic agent, avoids the interference and leakage of components in the complex system.

【学位授予单位】：哈尔滨工业大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ136.12

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