羟基磷灰石粉体及其多孔陶瓷的制备研究
发布时间：2018-07-26 12:13
【摘要】：在生物医用材料领域,对羟基磷灰石(简称HAP)的研究一直都是热门课题。由于羟基磷灰石与人骨成分极为相似,同时还具有较强的生物活性和生物相容性,所以羟基磷灰石是骨缺损修复最受追捧的原材料之一。但是人体骨骼的结构十分复杂,例如人体骨骼的大型棒骨的结构由内而外呈梯度孔结构,最外层的骨密质具有很强的力学性能,内部的骨松质具有三维的梯度孔结构。当人体骨骼由于疾病、外伤等因素缺损时,就要求修复材料由内而外具备与人体骨骼相似的梯度孔结构。目前合成结晶度较高的HAP粉体以及制备孔隙率和孔径尺寸可控、力学性能良好的HAP多孔陶瓷仍未能很好的解决。本文在合成羟基磷灰石粉体以及制备其多孔陶瓷方面进行了有益的尝试,并取得了一定的以下成果:一、采用化学沉淀法合成羟基磷灰石粉体。以氢氧化钙和磷酸为原料合成了HAP粉体。结果表明,Ca/P摩尔比是影响产物物相组成的重要因素,当Ca/P摩尔比为1.67时,合成产物为较纯的HAP粉体。反应温度也是影响产物结晶度的重要因素,当水浴温度和热处理温度分别为60℃和900℃时,合成产物为结晶度较好的HAP粉体。二、运用稳定颗粒微乳液法制备了HAP多孔陶瓷。结果表明,随着烧结温度增加,HAP多孔陶瓷的孔隙率逐渐减小,抗折强度逐渐增加。当烧结温度达到1200℃时,孔结构分布均匀,烧结良好,孔隙率为78.5%,抗折强度为1.69MPa。三、采用熔盐法制备了HAP模板晶粒,通过正交实验讨论HAP/熔盐质量比、热处理温度、保温时间对晶粒尺寸和微观形貌的影响。当HAP/熔盐质量比1:3,热处理温度650℃,保温时间3h,制备出的HAP模板晶粒发育良好,晶粒尺寸为15-25?m,符合增韧HAP多孔陶瓷的要求。四、采用模板晶粒强韧化HAP多孔陶瓷,制备了高孔隙率、孔径均一并具有高抗折强度的HAP多孔陶瓷。当模板晶粒掺合量为10 wt%时,HAP多孔陶瓷的孔隙率为68.22%,抗折强度为5.19MPa。
[Abstract]:In the field of biomedical materials, the study of hydroxyapatite (HAP) has been a hot topic. Hydroxyapatite is one of the most popular materials for bone defect repair because it is very similar to human bone and has strong bioactivity and biocompatibility. However, the structure of human skeleton is very complicated, for example, the structure of human bone is gradient pore structure from inside to outside, the outermost dense bone has very strong mechanical properties, and the internal cancellous bone has three dimensional gradient pore structure. When the human skeleton is damaged by disease and trauma, it is necessary to have the gradient pore structure similar to the human skeleton from inside to outside. At present, HAP powders with high crystallinity and controllable porosity and pore size have been synthesized, and HAP porous ceramics with good mechanical properties have not been solved. In this paper, hydroxyapatite powder and its porous ceramics have been prepared and some achievements have been made. Firstly, hydroxyapatite powder was synthesized by chemical precipitation method. HAP powder was synthesized from calcium hydroxide and phosphoric acid. The results show that the molar ratio of Ca / P is an important factor affecting the phase composition of the product. When the molar ratio of Ca/P is 1.67, the synthesized product is a pure HAP powder. The reaction temperature is also an important factor affecting the crystallinity of the product. When the temperature of water bath and heat treatment are 60 鈩，
本文编号：2145975
[Abstract]:In the field of biomedical materials, the study of hydroxyapatite (HAP) has been a hot topic. Hydroxyapatite is one of the most popular materials for bone defect repair because it is very similar to human bone and has strong bioactivity and biocompatibility. However, the structure of human skeleton is very complicated, for example, the structure of human bone is gradient pore structure from inside to outside, the outermost dense bone has very strong mechanical properties, and the internal cancellous bone has three dimensional gradient pore structure. When the human skeleton is damaged by disease and trauma, it is necessary to have the gradient pore structure similar to the human skeleton from inside to outside. At present, HAP powders with high crystallinity and controllable porosity and pore size have been synthesized, and HAP porous ceramics with good mechanical properties have not been solved. In this paper, hydroxyapatite powder and its porous ceramics have been prepared and some achievements have been made. Firstly, hydroxyapatite powder was synthesized by chemical precipitation method. HAP powder was synthesized from calcium hydroxide and phosphoric acid. The results show that the molar ratio of Ca / P is an important factor affecting the phase composition of the product. When the molar ratio of Ca/P is 1.67, the synthesized product is a pure HAP powder. The reaction temperature is also an important factor affecting the crystallinity of the product. When the temperature of water bath and heat treatment are 60 鈩，
本文编号：2145975
本文链接：https://www.wllwen.com/kejilunwen/huagong/2145975.html
