稳健统计在快速生物降解性试验质量分析中的应用

发布时间：2018-06-26 12:05

本文选题：苯甲酸钠 + 快速生物降解性试验　；参考：《生态毒理学报》2016年06期

【摘要】：快速生物降解性试验在新化学物质的生态毒理测试中占据重要地位,其测试数据的可靠性直接影响后续的测试策略和物质的申报登记、以及新化学物质进入环境后的风险管理。为研究OECD 301系列试验(301B、301D和301F)的质量,选用本机构近5年来积累的标准化物质苯甲酸钠14 d快速生物降解率数据,首次采用稳健统计技术,以稳健总计统计量的Z比分数作为评价指标,对各试验数据和试验系统的质量开展评估。结果显示,当301B、301D和301F试验的苯甲酸钠降解率分别在63.8%~88.0%、63.4%~89.2%和66.0%~99.8%范围内时,表明测试结果满意,该批次试验数据质量良好;若苯甲酸钠降解率不在此范围,则表明测试结果可能存在问题,甚至得到的可能是错误数据,需要进一步验证。据此提出了对实际测试工作具有指导意义的质量分析对照表,以期为测试机构开展新化学物质快速生物降解性试验时的质量分析提供参考。
[Abstract]:The rapid biodegradability test plays an important role in the ecotoxicological testing of new chemicals. The reliability of the test data directly affects the subsequent test strategies and the declaration and registration of substances, as well as the risk management after the new chemicals enter the environment. In order to study the quality of OECD301 series tests (301BX 301D and 301F), the fast biodegradable rate data of sodium benzoate, a standardized substance accumulated in the past 5 years, was selected for the first time, and the robust statistical technique was used for the first time. The Z ratio score of robust aggregate statistics is used as the evaluation index to evaluate the quality of each test data and test system. The results showed that, when the degradation rate of sodium benzoate in 301D and 301F tests was within 63.888. 0% and 66.0% 99.8%, respectively, the test results were satisfactory and the quality of the batch test data was good; if the degradation rate of sodium benzoate was not in this range, It indicates that the test results may be problematic, and even the error data may be obtained, which needs further verification. Based on this, a quality analysis comparison table is put forward, which can be used as a reference for the rapid biodegradability test of new chemicals.
【作者单位】：广东省微生物分析检测中心生态毒理与环境安全实验室;广东省微生物研究所广东省菌种保藏与应用重点实验室;省部共建华南应用微生物国家重点实验室;佛山市环境健康与安全评价研究中心;
【基金】：新材料环境健康安全评价科技创新服务平台(广东省科技计划项目,2013B090800004)
【分类号】：X171.5

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