藻红外测试多元有机药品联合作用偏差系数分析
发布时间：2018-11-15 06:30
【摘要】：藻红外测试联合作用偏差系数评价法作为一种创新性的联合作用评价体系,其偏差系数值直接关系到联合作用评价结果,因此偏差系数值至关重要。目前,联合作用偏差系数法偏差系数0.42,用于二元联合作用评价效果很好,但用于三元、四元、五元联合作用评价效果怎样,需要实验研究认知。为了研究多元联合作用类型与偏差系数的关系,本研究开展了苯、甲苯、二甲苯、氯苯、三氯甲烷等五种药品的多元联合作用测试实验,通过同药相加作用测试和异药联合作用测试分析多元联合作用与偏差系数的关系。研究结果如下:实验结果:(1)当取偏差系数值为0.42时,藻红外测试三元,四元,五元有机药品同药联合作用实验中相加作用重现性的出现率分别为40%,0%,40%。(2)根据偏差系数计算式得到三元联合作用作用的平均偏差系数为0.76,四元的为0.78,五元的为0.79,取其平均值得到总均偏差系数为0.78.(3)当取偏差系数值为0.78时,三元,四元,五元有机药品同药相加实验中相加作用重现性的出现率均为100%(4)当偏差系数值取0.42时,三元,四元,五元有机药品异药联合作用实验中拮抗作用重现性的出现率分别为90%,100%,100%(5)当偏差系数取0.78时,三元,四元,五元有机药品异药联合作用实验中拮抗作用重现性的出现率分别为40%,0%,0%研究结论:(1)偏差系数值0.42仅适合二元联合作用评价。(2)多元联合作用与偏差系数的关系是元数增加偏差系数增大,即联合作用评价的偏差系数值是二元三元四元五元。
[Abstract]:As an innovative joint action evaluation system, the deviation coefficient value of algal infrared test is directly related to the result of joint action evaluation, so the deviation coefficient value is very important. At present, the deviation coefficient of the method of deviation coefficient of combined action is 0.42, which is very effective in the evaluation of binary combined action, but it is necessary to study the cognition of experiment for the evaluation effect of ternary, quaternary and five-element combined action. In order to study the relationship between the type of multicomponent combined action and the deviation coefficient, the multicomponent combined action test of benzene, toluene, xylene, chlorobenzene and chloromethane was carried out. The relationship between the multivariate combined action and the deviation coefficient was analyzed by the additive test of the same drug and the combined action test of the heteropharmaceuticals. The results are as follows: (1) when the deviation coefficient is 0.42, the reproducibility of additive action in the experiments of ternary, quaternary and five-component organic drugs is 40%. (2) according to the formula of deviation coefficient, the average deviation coefficient of ternary combined action is 0.76, that of quaternion is 0.78, and that of five-element is 0.79. The mean deviation coefficient is 0.78. (3) when the deviation coefficient is 0.78, the mean deviation coefficient is three or four elements. The reproducibility of additive action was 100% (4) when the coefficient of deviation was 0.42, the reproducibility of additive action was three yuan and four yuan. The reproducibility of antagonistic action in the combination experiment of five-component organic drugs and heteropharmaceuticals was 90% 100% (5) when the deviation coefficient was 0.78, three yuan, four yuan, The reproducibility of antagonism in the combination of five organic drugs and heteropharmaceuticals was 40%. The conclusion of this study is as follows: (1) the deviation coefficient value of 0.42 is only suitable for the evaluation of binary combination action. (2) the relationship between the multivariate combination action and the deviation coefficient is the increase of the coefficient of deviation by increasing the number of variables. That is to say, the deviation coefficient value of joint action evaluation is binary ternary quaternion and quintuple.
【学位授予单位】：重庆大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：X832
本文编号：2332386
[Abstract]:As an innovative joint action evaluation system, the deviation coefficient value of algal infrared test is directly related to the result of joint action evaluation, so the deviation coefficient value is very important. At present, the deviation coefficient of the method of deviation coefficient of combined action is 0.42, which is very effective in the evaluation of binary combined action, but it is necessary to study the cognition of experiment for the evaluation effect of ternary, quaternary and five-element combined action. In order to study the relationship between the type of multicomponent combined action and the deviation coefficient, the multicomponent combined action test of benzene, toluene, xylene, chlorobenzene and chloromethane was carried out. The relationship between the multivariate combined action and the deviation coefficient was analyzed by the additive test of the same drug and the combined action test of the heteropharmaceuticals. The results are as follows: (1) when the deviation coefficient is 0.42, the reproducibility of additive action in the experiments of ternary, quaternary and five-component organic drugs is 40%. (2) according to the formula of deviation coefficient, the average deviation coefficient of ternary combined action is 0.76, that of quaternion is 0.78, and that of five-element is 0.79. The mean deviation coefficient is 0.78. (3) when the deviation coefficient is 0.78, the mean deviation coefficient is three or four elements. The reproducibility of additive action was 100% (4) when the coefficient of deviation was 0.42, the reproducibility of additive action was three yuan and four yuan. The reproducibility of antagonistic action in the combination experiment of five-component organic drugs and heteropharmaceuticals was 90% 100% (5) when the deviation coefficient was 0.78, three yuan, four yuan, The reproducibility of antagonism in the combination of five organic drugs and heteropharmaceuticals was 40%. The conclusion of this study is as follows: (1) the deviation coefficient value of 0.42 is only suitable for the evaluation of binary combination action. (2) the relationship between the multivariate combination action and the deviation coefficient is the increase of the coefficient of deviation by increasing the number of variables. That is to say, the deviation coefficient value of joint action evaluation is binary ternary quaternion and quintuple.
【学位授予单位】：重庆大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：X832
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