土壤中多溴联苯醚的生物利用度和生物有效性对比研究
发布时间：2019-01-24 16:45
【摘要】：多溴联苯醚(PBDEs)属于典型的持久性有机污染物(POPs),具有环境持久性、生物富集性、生物毒性和长距离传输性等特点,会对人体产生一定的危害。生物利用度和生物有效性是评估污染物人体暴露时常用的两个校正因子,本文的目的是测定土壤中PBDEs的生物有效性和生物利用度,探讨其相关性,为进一步优化体外模拟实验测定生物有效性奠定基础。研究了广东贵屿地区18个土壤样品中14种PBDEs的浓度水平和同系物分布特征。结果表明,所有的样品中都检测到了PBDEs,14种PBDEs的总浓度范围为75.0?74740 ng/g dw。与国内外其他地区的土壤样品相比,处于较高水平。BDE209是最主要的PBDEs同系物,占Σ14PBDEs的75.7?99.0%,这与一些国内其他研究的结果类似。由于BDE209是十溴工业品的主要成分,因此贵屿地区的电子垃圾中所使用的阻燃剂主要为十溴工业品。为了研究土壤样品中PBDEs的生物利用度,对其中的五个样品进行了3次的重复测定。利用小鼠模型,采用灌胃的方式对小鼠进行口服暴露,测定不同组织中PBDEs的含量,计算其生物利用度。结果表明PBDEs单体的生物利用度范围在0.7?48%之间。对5个土壤综合研究发现,PBDEs同系物的平均生物利用度与其疏水性成负相关。此外,还发现PBDEs的平均生物利用度与土壤中有机质含量之间没有相关性。利用胃肠模拟技术研究五个土壤样品中PBDEs的生物有效性,其范围为1.6?49.8%。通过对生物利用度和生物有效性的线性回归分析,发现BDE47、85、99、100和183等5种同系物的平均生物利用度和生物有效性的数值之间存在显著的线性相关(y=1.002x+0.634,R2=0.938,p=0.006),说明本实验所使用的体外胃肠模拟方法可以初步用于预测土壤样品中一些PBDEs同系物的生物利用度。
[Abstract]:Polybrominated diphenyl ether (PBDEs), a typical persistent organic pollutant (POPs), has the characteristics of environmental persistence, bioconcentration, biotoxicity and long-distance transport, which will cause certain harm to human body. Bioavailability and bioavailability are two commonly used correction factors in the assessment of human exposure to pollutants. The purpose of this paper is to determine the bioavailability and bioavailability of PBDEs in soil, and to explore the correlation between bioavailability and bioavailability. It lays a foundation for further optimization of bioavailability in vitro simulation experiment. The concentration level and homologue distribution of 14 PBDEs species in 18 soil samples from Guiyu area Guangdong Province were studied. The results showed that the total concentration range of PBDEs,14 species PBDEs was 75.0 ~ 74740 ng/g dw.. Compared with the soil samples from other regions at home and abroad, BDE209 is the most important homologue of PBDEs, accounting for 75.7 ~ 99.0 of 危 14PBDEs, which is similar to some other studies in China. Because BDE209 is the main component of decabromine industrial products, the flame retardants used in electronic waste in Guiyu area are mainly decabromine industrial products. In order to study the bioavailability of PBDEs in soil samples, five of them were determined three times. The mice were exposed orally by gavage to determine the content of PBDEs in different tissues and calculate its bioavailability. The results showed that the bioavailability of PBDEs monomer was in the range of 0.748%. The average bioavailability of PBDEs homologues was negatively correlated with their hydrophobicity. In addition, there was no correlation between the average bioavailability of PBDEs and the content of organic matter in soil. The bioavailability of PBDEs in five soil samples was studied by gastrointestinal simulation technique. By linear regression analysis of bioavailability and bioavailability, it was found that there was a significant linear correlation between the average bioavailability and bioavailability of five homologues such as BDE47,85,99100 and 183 (YY 1.002x 0.634R20.938). This method can be used to predict the bioavailability of some PBDEs congeners in soil samples.
【学位授予单位】：上海大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：X833
本文编号：2414638
[Abstract]:Polybrominated diphenyl ether (PBDEs), a typical persistent organic pollutant (POPs), has the characteristics of environmental persistence, bioconcentration, biotoxicity and long-distance transport, which will cause certain harm to human body. Bioavailability and bioavailability are two commonly used correction factors in the assessment of human exposure to pollutants. The purpose of this paper is to determine the bioavailability and bioavailability of PBDEs in soil, and to explore the correlation between bioavailability and bioavailability. It lays a foundation for further optimization of bioavailability in vitro simulation experiment. The concentration level and homologue distribution of 14 PBDEs species in 18 soil samples from Guiyu area Guangdong Province were studied. The results showed that the total concentration range of PBDEs,14 species PBDEs was 75.0 ~ 74740 ng/g dw.. Compared with the soil samples from other regions at home and abroad, BDE209 is the most important homologue of PBDEs, accounting for 75.7 ~ 99.0 of 危 14PBDEs, which is similar to some other studies in China. Because BDE209 is the main component of decabromine industrial products, the flame retardants used in electronic waste in Guiyu area are mainly decabromine industrial products. In order to study the bioavailability of PBDEs in soil samples, five of them were determined three times. The mice were exposed orally by gavage to determine the content of PBDEs in different tissues and calculate its bioavailability. The results showed that the bioavailability of PBDEs monomer was in the range of 0.748%. The average bioavailability of PBDEs homologues was negatively correlated with their hydrophobicity. In addition, there was no correlation between the average bioavailability of PBDEs and the content of organic matter in soil. The bioavailability of PBDEs in five soil samples was studied by gastrointestinal simulation technique. By linear regression analysis of bioavailability and bioavailability, it was found that there was a significant linear correlation between the average bioavailability and bioavailability of five homologues such as BDE47,85,99100 and 183 (YY 1.002x 0.634R20.938). This method can be used to predict the bioavailability of some PBDEs congeners in soil samples.
【学位授予单位】：上海大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：X833
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相关期刊论文 前2条
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，本文编号：2414638
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