Oxidation state specific analysis of arsenic species in tiss

发布时间：2021-02-20 11:01

　　Arsenic methyltransferase（As3mt） catalyzes the conversion of inorganic arsenic（i As） to its methylated metabolites, including toxic methylarsonite（MAs^Ⅲ） and dimethylarsinite（DMAs^Ⅲ）. Knockout（KO） of As3 mt was shown to reduce the capacity to methylate i As in mice. However, no data are available on the oxidation states of As species in tissues of these mice. Here, we compare the oxidation states of As species in tissues of male C57BL/6 As3mt-KO and wild-type（WT） mice exposed... 

【文章来源】：Journal of Environmental Sciences. 2016,49(11)

【文章页数】：9 页

【文章目录】：
Introduction
1. Materials and methods
    1.1. Arsenicals
    1.2. Mice and treatments
    1.3. Speciation analysis of As by HG-CT-AAS
    1.4. Statistical analysis
2. Results and discussion
    2.1. Water consumption and body weights
    2.2. Effect of genotype on As speciation in tissues
    2.3. Comparison of the tissue levels of As
3. Conclusions



本文编号：3042670