羟基磷灰石的合成及应用研究进展

发布时间：2018-03-09 09:42

本文选题：羟基磷灰石　切入点：骨修复及替代材料　出处：《人工晶体学报》2017年09期 　论文类型：期刊论文

【摘要】：羟基磷灰石不仅具有较好的稳定性、生物活性和生物相容性,还具有良好的骨传导作用、生物可分解及诱导骨形成的能力,是人体骨损伤时性能优良且近于理想的骨修复及替代材料。但由于其强度低、韧性差、不易成型等自身力学性能的制约,目前尚未得到广泛应用。制备综合性能优越的羟基磷灰石及其更加理想的复合材料已成为近年来研究的重心和热点。笔者根据羟基磷灰石的研究现状,综述了羟基磷灰石的起源与发展、制备方法、应用及发展前景。重点剖析了由水热法到仿生法发展过程中多种制备方法的优缺点,并进一步探讨了由致密到多孔、由单一到复合、甚至多相复合的应用发展历程和精确控制其复合材料的微观结构与骨材料结构的相似度,研究合成新型仿生骨来达到临床使用要求的发展前景。
[Abstract]:Hydroxyapatite not only has good stability, bioactivity and biocompatibility, but also has good bone conduction, biodegradability and ability to induce bone formation. It is an excellent and close to ideal bone repair and substitute material for human bone injury. However, due to its low strength, poor toughness, and difficult to form, it is restricted by its own mechanical properties. At present, the preparation of hydroxyapatite with superior comprehensive properties and its more ideal composite materials has become the focus and hotspot of research in recent years. According to the present research situation of hydroxyapatite, The origin, development, preparation method, application and development prospect of hydroxyapatite are reviewed. The advantages and disadvantages of various preparation methods from hydrothermal method to bionic method are analyzed, and the development from dense to porous is discussed. From single to composite, or even multiphase composite, the development process of application and accurate control of the microstructure of the composite and the similarity between the bone structure and the microstructure of the composite are studied and synthesized to achieve the development prospect of clinical application.
【作者单位】：中国矿业大学(北京)地球科学与测绘工程学院;首都医科大学宣武医院;
【基金】：国家自然科学基金(41602171) 北京市自然科学基金(8164062) 北京市科技新星计划(2015B081) 北京市优秀人才计划(2014000020124G164)
【分类号】：R318.08;TQ132.32

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