刺激响应性石墨烯微胶囊的声化学制备研究

发布时间：2018-03-30 17:39

本文选题：药物载体　切入点：声化学　出处：《吉林大学》2017年硕士论文

【摘要】：近年来,药物传输体系在生物医用领域的应用得到了深入的研究。在众多的药物传输体系中,同时具有靶向功能和刺激响应性的药物传输体系在肿瘤治疗中具有显著的优势,这是由于其可以通过磁靶向和分子靶向功能将药物快速的运输到目标部位,并通过一些智能响应(温度响应、pH响应和还原响应等)控制药物的释放。本文旨在研究多功能氧化石墨烯基胶囊的声化学制备及其性能。利用氧化石墨烯、壳聚糖、叶酸和磁性纳米粒子等材料,制备出具有不同功能的氧化石墨烯基载药胶囊。此外,研究了胶囊的载药能力和智能控制释放药物的性能。1.通过声化学法成功的制备了同时具有pH和还原双响应性的磁性氧化石墨烯微胶囊(MGOMCs)。其中,巯基化的氧化石墨烯(TG)相互交联形成囊壁,含有油性Fe3O4纳米粒子(OA-Fe3O4 NPs)和香豆素6(C6,一种疏水性药物模型)的油相为囊芯。主要考察了超声强度、超声时间、TG的浓度以及油水比对微胶囊的形貌、大小、包覆率的影响。此外,还研究了MGOMCs的磁靶向性能和智能响应释放性能。2.通过声化学法成功的制备了叶酸修饰的具有多重响应性的氧化石墨烯基纳米胶囊(FA-MRMGONCs)。其中,位于水相中的TG和叶酸修饰的巯基化壳聚糖相互交联形成囊壁,含有OA-Fe3O4 NPs和C6的油相为囊芯。研究表明:1)位于纳米胶囊囊壁上的叶酸分子和囊内的OA-Fe3O4 NPs,可以使其具有良好的分子靶向性和磁靶向性;2)制备的纳米胶囊的外壳可以有效的保护所装载的药物,使药物在运输过程中不发生泄漏;3)所得到的纳米胶囊具有光热效应和光响应释放性能,可以用于肿瘤的光热治疗;4)纳米胶囊是由巯基相互交联而成,使其具有良好的还原响应性,可以有效的控制药物的释放。
[Abstract]:In recent years, the application of drug delivery system in the field of biomedicine has been deeply studied. In many drug delivery systems, drug delivery systems with both targeted and stimulative response have significant advantages in tumor treatment. This is because it can quickly transport drugs to target sites through both magnetic and molecular targeting functions. Some intelligent responses (temperature response, pH response, reduction response, etc.) are used to control the release of drugs. The purpose of this paper is to study the sonochemical preparation and properties of multifunctional graphene oxide capsules. In addition, graphene oxide based drug-loaded capsules with different functions were prepared from folic acid and magnetic nanoparticles. The drug loading ability of capsules and the properties of intelligent controlled drug release were studied. 1. The magnetic graphene oxide microcapsules with both pH and reduction response were successfully prepared by sonochemical method. Mercaptolized graphene oxide (TGO) is cross-linked to form a capsule wall, containing the oil phase of Fe3O4 nanoparticles (OA-Fe _ 3O _ 4 NPs) and coumarin 6H _ 3O _ 6, a hydrophobic drug model. The influence of the concentration of TG and the ratio of oil to water on the morphology, size and coating rate of microcapsules. The magnetic targeting properties and intelligent response release properties of MGOMCs were also studied. 2. Folic acid modified graphene oxide nanocapsules FA-MRMGONCs1 were successfully prepared by sonochemical method. In aqueous phase, TG and folic acid modified mercaptochitosan crosslinked each other to form cysts. The oil phase containing OA-Fe3O4 NPs and C6 is the core. The study shows that the folate molecule located on the wall of the capsule and the OA-Fe3O4 NPs in the capsule can make the capsule have good molecular targeting and magnetic targeting. Effective protection of loaded drugs, The nanocapsule, which can be used for photothermal therapy of tumor, is composed of sulfhydryl group cross-linking. So that it has a good reduction response, can effectively control the release of drugs.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ127.11;TQ460.1

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