医用纯Mg表面多种复合处理膜层的组织结构和体内外性能

发布时间：2018-04-14 03:09

本文选题：纯Mg + 超声微弧氧化　；参考：《金属学报》2017年10期

【摘要】：为了提高医用纯Mg的耐蚀性和生物活性,采用超声微弧氧化(UMAO)、碱处理(OH)、硅烷转化膜处理(SCA)和自组装丝素蛋白(SF)多种处理方法,在Mg表面形成多元膜层(UMAO-OH-SCA-SF),通过SEM、红外光谱、电化学测试、细胞实验和动物植入实验,研究膜层表面形貌、组织结构、耐腐蚀性能、细胞活性和体内骨生长。结果表明,超声微弧氧化膜层以MgO为主相,碱羟基利于与硅烷偶联形成Si-O-Mg膜,再自组装丝素,随着浸泡丝素蛋白时间增加,丝素蛋白的结构由无规卷曲向b-折叠转变,多元复合膜层提高了自腐蚀电位,自腐蚀电流密度降低了2个数量级。多元复合膜层更能促进成骨细胞的增殖、黏附与分化,具有良好的早期骨整合能力和在纯Mg降解过程中控制Mg~(2+)溶出能力,其中UMAO-OH-SCA-SF/1.5h最佳。
[Abstract]:In order to improve the corrosion resistance and biological activity of medical pure mg, UMAO (UMAO), UMAO (alkali-treated), SCA- (silane conversion film) and SF (self-assembled silk fibroin) were prepared on mg surface by ultrasonic micro-arc oxidation (UMAO-OH-SCA-SFN), and the UMAO-OH-SCA-SFs were prepared by means of SEM, IR spectra.Electrochemical tests, cell tests and animal implantation experiments were conducted to study the surface morphology, tissue structure, corrosion resistance, cell activity and bone growth in vivo.The results showed that MgO was the main phase of ultrasonic micro-arc oxidation film, alkali-hydroxyl group was favorable for coupling with silane to form Si-O-Mg film, and then self-assembled fibroin. With the increase of soaking time of fibroin, the structure of fibroin changed from random crimp to b-fold.The multicomponent composite film increases the corrosion potential and reduces the corrosion current density by 2 orders of magnitude.The multicomponent composite membrane layer could promote the proliferation, adhesion and differentiation of osteoblasts, and had good ability of early bone integration and controlling the dissolution of Mg~(2 during the degradation of pure mg, among which UMAO-OH-SCA-SF/1.5h was the best.
【作者单位】：佳木斯大学黑龙江省高校生物医学材料重点实验室;
【基金】：国家自然科学基金面上项目No.31370979~~
【分类号】：R318.08;TG174.4

【相似文献】