纯钛表面镁离子改性后磷灰石沉积、蛋白质吸附及成骨细胞初期反应的研究（英文）

发布时间：2018-07-04 08:23

本文选题：钛 + 骨传导性　；参考：《稀有金属材料与工程》2017年06期

【摘要】：通过一种简单可行的方法对钛表面进行镁离子改性。首先将纯钛放入高浓度氢氧化钠(NaOH)溶液中进行碱化处理,然后再转移至稀氯化镁(MgCl_2)溶液中进行离子交换,最后进行热处理,在纯钛试样表面形成了含有钛酸镁成分的3D纳米网状结构。对试样的表面形貌、粗糙度和化学组成进行了分析;考察了试样在模拟人工体液中诱导羟基磷灰石沉积的能力;以牛血清白蛋白为模型,研究了表面改性对纯钛试样蛋白吸附能力的影响;评价了MC3T3-E1成骨细胞在试样表面的附着、铺展和增殖。结果表明,与钠(Na)离子改性相比,镁离子改性加快了羟基磷灰石在试样表面的沉积,并明显促进了蛋白吸附。此外,镁离子改性促进了成骨细胞附着、铺展及随后的增殖。
[Abstract]:Magnesium ion modification on titanium surface was carried out by a simple and feasible method. Titanium was first alkalized in high concentration sodium hydroxide (NaOH) solution, then transferred to MgCl2 solution for ion exchange, and finally heat treated. A 3D nano mesh structure containing magnesium titanate was formed on the surface of pure titanium sample. The surface morphology, roughness and chemical composition of the sample were analyzed. The ability of the sample to induce hydroxyapatite deposition in simulated artificial body fluid was investigated. The effect of surface modification on protein adsorption of pure titanium samples was studied, and the adhesion, spreading and proliferation of MC3T3-E1 osteoblasts on the sample surface were evaluated. The results showed that magnesium ion modification accelerated the deposition of hydroxyapatite on the surface of the sample and promoted the protein adsorption. In addition, magnesium ion modification promotes osteoblast attachment, spreading and subsequent proliferation.
【作者单位】：江苏科技大学;
【基金】：Priority Academic Program Development of Jiangsu Higher Education Institutions Doctor Project of Jiangsu University of Science and Technology(635061402)
【分类号】：R318.08;TG174.4

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