镁合金全降解血管支架研究进展
发布时间：2018-08-18 21:36
【摘要】：全降解血管支架具有克服传统不可降解金属支架长期植入引起的慢性炎症、晚期支架血栓以及需长期服用抗血小板药物等问题的潜在优势,因此目前在世界范围内是介入医学工程领域研究开发的热点。镁合金全降解血管支架因兼具较高的支撑强度和生物可降解吸收特性,更是走在了全降解血管支架发展的前列。本文主要介绍国际上广泛关注的德国Biotronik公司镁合金全降解血管支架的研发历程,以及我国自主研发的AZ31、JDBM和MgZnYNd3种镁合金全降解血管支架研发现状。国内外大量的动物和临床实验表明,镁合金血管支架在体内是安全有效的,但其降解速率比预期稍快。通过建立新型合金体系并改善支架的结构和涂层,镁合金全降解血管支架性能将逐渐完善,并在不久的将来在治疗心血管疾病等方面发挥其重大作用。
[Abstract]:Fully degradable vascular stents have potential advantages in overcoming chronic inflammation caused by long-term implantation of traditional non-degradable metal stents, late stent thrombosis and long-term antiplatelet drugs. Therefore, it is a hot spot in the field of medical engineering research and development in the world. Magnesium alloy fully degradable vascular stents are in the forefront of the development of fully degradable vascular stents because of their high supporting strength and biodegradable absorption characteristics. This paper mainly introduces the research and development process of fully degradable vascular stents for magnesium alloys of Biotronik company in Germany, and the research and development status of AZ31 JDBM and MgZnYNd3 totally degradable vascular stents of magnesium alloys in China. A large number of animal and clinical experiments at home and abroad show that magnesium alloy vascular stent is safe and effective in vivo, but its degradation rate is a little faster than expected. By establishing a new alloy system and improving the structure and coating of the stent, the properties of the fully degradable vascular stent of magnesium alloy will be gradually improved, and will play an important role in the treatment of cardiovascular diseases in the near future.
【作者单位】： 北京大学深圳研究院;北京大学前沿交叉学科研究院;中国食品药品检定研究院;河北科技大学材料科学与工程学院;北京大学工学院材料科学与工程系;
【基金】：广东省自然科学基金项目Nos.2016A030310245和2016A030310244 中国博士后基金项目No.2016M591017 深圳市基础研究(自由探索)项目No.JCYJ20160427170611414~~
【分类号】：R318.08;TG146.22
本文编号：2190759
[Abstract]:Fully degradable vascular stents have potential advantages in overcoming chronic inflammation caused by long-term implantation of traditional non-degradable metal stents, late stent thrombosis and long-term antiplatelet drugs. Therefore, it is a hot spot in the field of medical engineering research and development in the world. Magnesium alloy fully degradable vascular stents are in the forefront of the development of fully degradable vascular stents because of their high supporting strength and biodegradable absorption characteristics. This paper mainly introduces the research and development process of fully degradable vascular stents for magnesium alloys of Biotronik company in Germany, and the research and development status of AZ31 JDBM and MgZnYNd3 totally degradable vascular stents of magnesium alloys in China. A large number of animal and clinical experiments at home and abroad show that magnesium alloy vascular stent is safe and effective in vivo, but its degradation rate is a little faster than expected. By establishing a new alloy system and improving the structure and coating of the stent, the properties of the fully degradable vascular stent of magnesium alloy will be gradually improved, and will play an important role in the treatment of cardiovascular diseases in the near future.
【作者单位】： 北京大学深圳研究院;北京大学前沿交叉学科研究院;中国食品药品检定研究院;河北科技大学材料科学与工程学院;北京大学工学院材料科学与工程系;
【基金】：广东省自然科学基金项目Nos.2016A030310245和2016A030310244 中国博士后基金项目No.2016M591017 深圳市基础研究(自由探索)项目No.JCYJ20160427170611414~~
【分类号】：R318.08;TG146.22
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