纯镁超声微弧氧化-植酸-镀锌生物膜层的制备与抗菌性

发布时间：2019-08-09 08:17

【摘要】：针对医用金属植入材料造成的术后组织感染问题,在纯镁超声微弧氧化-植酸处理工艺基础上,采用化学镀锌法引入具有抗菌性和生物活性的锌元素,探究不同化学镀锌含量对膜层抗菌性能的影响。通过XRD、SEM及能谱检测分析了膜层形貌和组织结构,采用覆膜法检验抗菌性能。结果表明:随着镀锌时间增长,膜层表面孔隙减少、膜层愈加致密,Zn含量(质量分数)增加,耐腐蚀性能提高;镀锌含量对膜层抗菌性能有直接影响,化学镀锌5 min时,Zn含量达1.50%,对大肠杆菌和金黄色葡萄球菌的抗菌率高达99%,明显优于镀锌1 min组和镀锌3 min组。纯镁超声微弧氧化-植酸膜层经化学镀锌处理后其抗菌性能随锌含量的提高而增强,化学镀锌5 min时,膜层具有较强的抗菌功能。
[Abstract]:In order to solve the problem of postoperative tissue infection caused by medical metal implantation materials, based on the ultrasonic micro-arc oxidation and phytic acid treatment of pure magnesium, zinc elements with antibacterial and biological activities were introduced by Electroless galvanizing method, and the effects of different contents of Electroless galvanizing on the antibacterial properties of the films were investigated. The morphology and microstructure of the film were analyzed by XRD,SEM and energy spectrum, and the antibacterial properties were tested by film coating method. The results showed that with the increase of galvanizing time, the pores on the surface of the film decreased, the film became denser, the content of Zn (mass fraction) increased, and the corrosion resistance of the film was improved, and the content of zinc plating had a direct effect on the antibacterial properties of the film. The content of Zn was 1.50% and the antibacterial rate against Escherichia coli and Staphylococcus aureus was 99%, which was obviously better than that of galvanized 1 min group and galvanized 3 min group. The antibacterial properties of pure magnesium ultrasonic micro-arc oxidation-phytic acid film increased with the increase of zinc content after Electroless galvanizing. When Electroless galvanizing for 5 min, the film had strong antibacterial function.
【作者单位】：佳木斯大学黑龙江省高校生物医学材料重点实验室;
【基金】：国家自然科学基金(3137097) 黑龙江省高校创新团队建设计划(2012TD010) 佳木斯大学研究生科技创新项目(LZR2015_17)
【分类号】：TG174.45

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