钛表面电化学法沉积掺锶羟基磷灰石涂层及其形貌控制

发布时间：2018-05-05 16:03

本文选题：掺锶羟基磷灰石 + 两步电沉积法　；参考：《浙江大学》2015年硕士论文

【摘要】：本文采用电化学法首先在不同电解液浓度条件下在钛金属基底表面沉积羟基磷灰石(HA)涂层,通过分析沉积电流随时间变化规律,使用扫描电子显微镜(SEM)观察涂层微观形貌,使用X射线衍射法(XRD)分析涂层物相组成,研究了随着电解液浓度的提高,相应地改变沉积电压和温度等实验参数,制备的涂层的微观形貌和物相的变化规律,总结出制备HA涂层的实验规律。其次也探讨了高低两种浓度的电解液中制备掺锶羟基磷灰石(SrHA)涂层的实验条件,结合第一部分实验所总结的规律,发现通过调控沉积电压、温度和时间,在两种电解液中加入一定比例的含锶电解质参与反应,均可制备出掺锶比例接近接近预期的SrHA涂层,也证实了Sr2+和Ca2+参与SrHA结晶形核的行为相似。最后采用两步电沉积法,将高低两种浓度的电解液条件下的涂层制备结合,并且在进行第二步沉积的高浓度电解液中加入重要的反应介质柠檬酸三钠(Na3Cit)。第二步沉积中,在柠檬酸根的吸附作用下晶核在原有的棒状结构侧面聚集组装,形成荆棘状结构涂层。体外离子释放实验和涂层接触角测试结果表明,两步电沉积均掺锶的荆棘状结构涂层具有快速的Sr2+释放速率和最佳的润湿性。在细胞增殖试验中,SrHA涂层受各自的Sr2+释放情况和微观形貌影响,表现出不同的促进细胞增殖情况,为可控地制备出在物相组成和微观结构上与人体磷灰石更为接近的生物医用材料开辟了新的方向。
[Abstract]:In this paper, the hydroxyapatite (HA) coating was deposited on titanium substrate with different electrolyte concentration by electrochemical method. The microstructure of the coating was observed by scanning electron microscope (SEM) by analyzing the variation of deposition current with time. The phase composition of the coating was analyzed by X-ray diffraction (XRD). With the increase of electrolyte concentration, the microstructure and phase change of the coating were studied by changing the experimental parameters such as deposition voltage and temperature. The experimental rule of HA coating was summarized. Secondly, the experimental conditions of preparing SrHA coating with strontium hydroxyapatite in high or low concentration electrolyte are also discussed. According to the rule summarized in the first part of the experiment, it is found that the deposition voltage, temperature and time can be adjusted by adjusting the deposition voltage, temperature and time. Adding a certain proportion of strontium-containing electrolyte to the two electrolytes to take part in the reaction, the Sr-doped SrHA coatings were prepared, and the behavior of Sr2 and Ca2 participating in the nucleation of SrHA was proved to be similar. Finally, a two-step electrodeposition method was used to prepare the coating under the conditions of high and low concentrations of electrolyte, and an important reaction medium, sodium citrate, was added to the high concentration electrolyte for the second step deposition. In the second step, the crystal nucleus is assembled on the side of the original rod-like structure by the adsorption of citrate to form a thorn-like structure coating. The ion release experiment in vitro and the contact angle test of the coating show that the Sr2 release rate and the wettability of the bramble structure coating with strontium doped in two steps are rapid and the best wettability can be obtained. In the cell proliferation test, the SrHA coating was affected by the release of Sr2 and the microcosmic morphology, and showed different effects on cell proliferation. It opens a new direction for the controllable preparation of biomedical materials which are closer to human apatite in terms of phase composition and microstructure.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TG174.4

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