增材制造制备Zn–Nd合金的成形质量、力学性能及抗炎活性（英文）

发布时间：2022-07-16 14:07

　　目的:锌具有良好的降解性能和生物相容性,被视为一种很有前途的骨修复材料。然而,锌金属作为骨植入物时的力学强度难以满足承重骨修复的需求,并存在炎症反应的风险。本文旨在探讨稀土钕合金化对锌骨植入物激光成形质量的影响,为改善锌合金的成形质量、提高力学性能及增加抗炎活性提供理论依据。创新点:1.在增材制造过程中,添加钕能够有效改善锌基合金的成形质量;2.稀土钕提高了锌基合金的力学性能,同时也赋予了抗炎活性。方法:1.通过实验对比锌钕合金的表面形貌,计算出相应的致密度,并分析钕对锌基合金成形质量的影响（图2）;2.基于不同实验对比锌钕合金的微观组织结构及力学强度的变化,并探讨稀土钕提高力学性能的原因（图3～5和表1）;3.通过电化学实验和浸泡实验,分析稀土钕对降解性能的影响（图6和7）;4.基于体外生物学实验,对比分析钕对抗炎活性和细胞活性的影响（图8和9）。结论:1.稀土钕提高了激光增材制造锌合金的成形质量,并使其致密化率高达98.71%;2.钕合金化有助于晶粒细化和第二相强化,使极限抗拉强度提高到了（119.3±5.1） MPa;3.钕合金化能抑制促炎因子的释放,促进抗炎因子的释放,进而使锌... 

【文章页数】：16 页

【文章目录】：
1 Introduction
2 Materials and methods
    2.1 Material and sample fabrication
    2.2 Microstructural characterization
    2.3 Mechanical tests
    2.4 Electrochemical and immersion experiments
    2.5 Evaluation of anti-inflammatory activity
    2.6 Cytotoxicity assay
    2.7 Statistical analysis
3 Results
    3.1 Formation quality and microstructure evolution
    3.2 Mechanical properties
    3.3 Corrosion behavior
    3.4 Anti-inflammatory properties
    3.5 Cytotoxicity
4 Discussion
    4.1 Forming quality and microstructural features
    4.2 Influence of alloying treatment on mechanical properties
    4.3 Corrosion behavior and anti-inflammatory activity of Zn–Nd alloy
5 Conclusions


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