片剂生产型三维打印设备关键技术研究

发布时间：2018-06-17 12:23

本文选题：片剂生产型 + 三维打印　；参考：《华中科技大学》2013年硕士论文

【摘要】：在生产实践中，对片剂生产型系统有着广泛的需求，如医学上的药片生产、烟草行业滤嘴生产、电子行业的小型器件生产等。采用传统方式很难制造具有复杂结构的小型片剂，将三维打印技术应用于制造有复杂结构的小型片剂，具有巨大的发展前景和意义。要实现三维打印技术的生产化，需研究生产型三维打印设备中的几项关键技术STL分层填充软件、喷射溶液配方、粉材配方、工艺参数以及缺陷分析，以使得三维打印设备能够达到生产化、工业化的要求。本文在自主研发的三维打印试验设备上进行三维打印工艺研究，试验设备采用Xaar128/80喷头作为打印喷头。分析了STL文件的特性以及三维打印设备对数据格式的要求，研究了STL文件分层及填充算法。采用切平面与三角面片求交的方法对STL文件进行分层，并采用扫描线填充方法对轮廓进行填充。在分析研究了三维打印成型机理的基础上，研发了能够用于食品领域的材料配方。针对不同的配方进行打印实验，获得了较好的成型件。通过对成型件的宏观和微观分析，比较了不同配方对成型件的影响。通过实验分析研究了三维打印的工艺参数喷墨量、层厚、成型时间、喷头距粉材距离以及环境条件等，并设定了合适的范围。针对三维打印过程中出现的缺陷表面模糊、翘曲、破碎，分析了其产生原因，并提出了改进方案。通过在自主研发的三维打印设备上进行实验，得出了基本符合需求的样品。表明本研究内容已经满足达到了片剂生产型设备的需求。对三维打印技术在片剂生产化领域的发展具有较大的意义。
[Abstract]:In the production practice, there is a wide demand for tablet production system, such as medical tablet production, tobacco industry filter production, electronics industry small device production. It is very difficult to manufacture small tablets with complex structure by traditional methods. It is of great development prospect and significance to apply 3D printing technology to manufacture small tablets with complex structures. In order to realize the production of 3D printing technology, it is necessary to study several key technologies in the production 3D printing equipment, such as STL layering and filling software, spray solution formula, powder formula, process parameters and defect analysis. So that the 3D printing equipment can meet the requirements of production and industrialization. In this paper, the 3D printing process is studied on the developed 3D printing test equipment. Xaar 128 / 80 nozzle is used as the printing nozzle. This paper analyzes the characteristics of STL files and the requirements of 3D printing equipment for data format, and studies the algorithm of STL file layering and filling. The STL file is stratified by the intersection of the tangent plane and the triangle slice, and the contour is filled by the scanning line filling method. On the basis of analyzing and studying the three-dimensional printing forming mechanism, the material formula which can be used in the field of food was developed. The printing experiments were carried out for different formulations, and good moulding parts were obtained. The effects of different formulations on the molded parts were compared by macroscopical and microcosmic analysis. The technological parameters of 3D printing, such as the amount of ink jet, the thickness of the layer, the forming time, the distance from the nozzle to the powder and the environmental conditions, were studied by experiments, and the appropriate range was set. In view of the surface blur, warping and breaking of the defects in the process of 3D printing, the causes of the defects are analyzed, and an improved scheme is put forward. Through the experiments on the self-developed three-dimensional printing equipment, the samples which basically meet the requirements are obtained. The results show that the content of this study has met the demand of tablet production equipment. It has great significance for the development of three-dimensional printing technology in the field of tablet production.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：TP334.8

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