广西壮族人群RTN4基因多态性及其单倍型与鼻咽癌易感性的关系

发布时间：2018-01-20 02:44

本文关键词： RTN基因鼻咽癌易感性单倍型　出处：《肿瘤防治研究》2017年03期 　论文类型：期刊论文

【摘要】：目的研究广西壮族人群RTN4基因多态性及其单倍型与鼻咽癌易感性之间的关系。方法运用DNA测序法和单碱基延伸PCR技术,检测广西壮族人群200例确诊为鼻咽癌患者(鼻咽癌组)和200例健康查体者(对照组)的RTN4基因rs2588510和rs1348528位点基因型,并分析RTN4基因的等位基因和单倍型频率。结果 RTN4基因多态性rs2588510和rs1348528位点在对照组和鼻咽癌组中的基因型和等位基因频率分布差异均无统计学意义。而两个位点在对照组和鼻咽癌组中单倍型CG频率分别为27.5%和34.8%,单倍型TA频率分别为0.7%和3.0%,鼻咽癌组单倍型CG和TA频率的分布差异显著高于对照组(P=0.007,OR=2.05,95%CI:1.21~3.46;P=0.001,OR=6.48,95%CI:1.69~24.9)。结论 RTN4基因多态性rs2588510和rs1348528位点的单倍型CG和TA可增加广西壮族人群个体鼻咽癌易感性。
[Abstract]:Objective to study the association of RTN4 gene polymorphism and haplotype with susceptibility to nasopharyngeal carcinoma in Guangxi Zhuang population. Methods DNA sequencing and single base extension PCR technique were used. 200 patients with nasopharyngeal carcinoma (NPC group) and 200 healthy volunteers (control group) in Guangxi Zhuang nationality were detected. Genotype of rs2588510 and rs1348528 loci of RTN4 gene. The allele and haplotype frequency of RTN4 gene were analyzed. There was no significant difference in genotype and allele frequency distribution of RTN4 polymorphism rs2588510 and rs1348528 loci in control group and nasopharyngeal carcinoma group, but there was no significant difference between the two loci in the control group and nasopharyngeal carcinoma group. The frequency of haplotype CG in radiation group and nasopharyngeal carcinoma group was 27.5% and 34.8%, respectively. The frequencies of haplotype TA were 0.7% and 3.0, respectively. The distribution of haplotype CG and TA in nasopharyngeal carcinoma group was significantly higher than that in control group. 95 CI: 1.21 and 3.46; P0. 001 ORA 6.48. 95 CI: 1.69 I 24.9). Conclusion the haplotype CG and TA at rs2588510 and rs1348528 loci of RTN4 gene polymorphism can increase the susceptibility to nasopharyngeal carcinoma in Guangxi Zhuang population.
【作者单位】：右江民族医学院附属医院生殖遗传实验室;右江民族医学院附属医院检验科;右江民族医学院;
【基金】：国家自然科学基金(81560461)
【分类号】：R739.63
【正文快照】： 0引言鼻咽癌(nasopharyngeal carcinoma,NPC)是一种具有明显的民族倾向和地理分布的头颈部恶性肿瘤,好发于中国南部。遗传、生活环境和年龄等多种因素相互作用可诱导鼻咽癌发生,其中遗传因素与鼻咽癌发生发展的关系成为鼻咽癌发病机制研究的热点[1-2]。RTN4基因属于网状蛋白家

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