内脂素rs13237989和rs13224516基因多态性与2型糖尿病的相关性研究

发布时间：2018-01-20 14:56

本文关键词： 型糖尿病内脂素单核苷酸多态性　出处：《检验医学与临床》2016年22期 　论文类型：期刊论文

【摘要】：目的探讨内脂素rs13237989和rs13224516基因多态性与广东地区2型糖尿病的相关性。方法收集2013年1月至2014年12月广州医科大学附属第二医院收治新诊断为2型糖尿病患者181例为病例组,另选择体检中心健康者180例为对照组,比较两组血清内脂素rs13237989位点C和T基因型与rs13224516位点A和C基因型的分布频率,并对病例组rs13237989和rs13224516位点不同基因型对应的生化指标进行比较,包括胆固醇(CHOL)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果内脂素rs13237989、rs13224516等位基因频率分布符合遗传定律,样本具有群体代表性,两个基因位点在两组间的基因型多态性分布和等位基因频率差异均无统计学意义(P0.05);Logistic回归分析显示,基因多态性与2型糖尿病无相关性(P0.05);病例组不同基因型携带者TG、CHOL、HDL-C、LDL-C水平差异无统计学意义(P0.05)。结论内脂素rs13237989与rs13224516基因多态性与广东地区2型糖尿病的发生无相关性。
[Abstract]:Objective to investigate the correlation of visfatin rs13237989 and rs13224516 gene polymorphism with type 2 diabetes in Guangdong. A total of second newly diagnosed hospital were collected from January 2013 to December 2014 in Guangzhou Medical University for patients with type 2 diabetes mellitus 181 cases and other 180 cases health examination center as control group, the frequency distribution between the two groups in serum visfatin rs13237989 loci C and T genotypes and rs13224516 loci A and C genotypes, compared the biochemical indexes and the cases of group rs13237989 and rs13224516 loci respectively, including cholesterol, triglycerides (CHOL) three (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C). The results of visfatin rs13237989, rs13224516 allele frequency distribution accords with the law of inheritance, the sample has the group representative, two loci in the two groups of genotype polymorphism Cloth and allele frequencies were not significantly different (P0.05); Logistic regression analysis showed that there was no correlation between gene polymorphism and type 2 diabetes mellitus (P0.05) patients with different genotype carriers; TG, CHOL, HDL-C, no statistically significant differences in the level of LDL-C (P0.05). The incidence of type 2 diabetes on visfatin rs13237989 and rs13224516 gene polymorphism in Guangdong area with no correlation.

【作者单位】：广州医科大学附属第五医院检验科;广州医科大学附属第二医院检验科;广东省广州市中医医院检验科;广东省广州市黄埔区红十字会医院检验科;
【基金】：广东省科技计划资助项目(2012B061700044) 广东省医学科研基金资助项目(A2012256)
【分类号】：R587.1;R440
【正文快照】： 糖尿病是常见病、多发病,是严重威胁人类健康的全球性疾病。30年来,由于我国经济的发展速度快、生活方式的不断改变和人口老龄化越来越严重,肥胖患病率不断增长,同时我国糖尿病患病率也快速增长[1],目前已经达到9.7%[2],60岁以上居民患病率达到19.6%[3],已给社会带来沉重的经

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