人类白细胞抗原DP基因多态性与特发性膜性肾病遗传易感性研究

发布时间：2018-01-29 07:52

本文关键词： 膜性肾病特发性 HLA-DP 单核苷酸多态性　出处：《现代预防医学》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨人类白细胞抗原(human leukocyte antigen,HLA)DP基因多态性与中国人群特发性膜性肾病(Idiopathic Membranous Nephropathy,IMN)遗传易感性的关系。方法选取185例特发性膜性肾病患者和405位健康对照作为研究对象,应用Taq Man-MGB探针基因分型方法检测HLA-DP基因多态性位点(rs3077和rs9277535)的基因型分布。结果采用多因素logistic回归分析,rs3077位点结果显示,突变基因型AA在特发性膜性肾病组中的频率均显著高于健康对照组(调整OR=1.92,95%CI=1.09-3.38);单倍型分析显示,与GG单倍型相比,携带AA单倍型的个体可增加特发性膜性肾病的患病风险;(调整OR=2.86,95%CI=1.58-5.58);此外,rs3077位点的突变基因型AA可增加特发性膜性肾病患者发生肾功能衰竭的风险(调整OR=3.11,95%CI=1.53-6.32)。结论 HLA-DP基因多态性与特发性膜性肾病遗传易感性存在关联,且与特发性膜性肾病患者的肾功能也具有相关性。
[Abstract]:Objective to investigate the human leukocyte antigen of human leukocyte antigen. HLA)DP gene polymorphism and idiopathic Membranous Nephropathy in Chinese patients with idiopathic membranous nephropathy. Methods 185 patients with idiopathic membranous nephropathy and 405 healthy controls were selected. Detection of polymorphic HLA-DP loci rs3077 and rs9277535 by Taq Man-MGB probe genotyping. Results multivariate logistic regression analysis was used. The results of rs3077 locus showed that the frequency of AA mutation genotype in idiopathic membranous nephropathy group was significantly higher than that in healthy control group (adjusted OR=1.92). 95. CII 1.09-3.38; Haplotype analysis showed that individuals with AA haplotype increased the risk of idiopathic membranous nephropathy compared with GG haplotype. (adjustment of ORA 2.86 / 95 / CI1.58-5.58); In addition, the mutation genotype AA at rs3077 increased the risk of renal failure in patients with idiopathic membranous nephropathy (adjusted for OR=3.11). Conclusion the polymorphism of HLA-DP gene is associated with the genetic susceptibility of idiopathic membranous nephropathy. It is also associated with renal function in patients with idiopathic membranous nephropathy.
【作者单位】：河北省中医院肾病科;天津中医药大学;河北医科大学;
【分类号】：R692
【正文快照】： 膜性肾病(Membranous Nephropathy,MN)是一种常见的成人原发性肾小球疾病,该病主要以肾小球毛细血管襻上皮侧弥漫性的免疫复合物沉积伴有肾小球基底膜增厚以及“钉突”形成为主要特征,是一种慢性难治性疾病[1]。其中,特发性膜性肾病(IdiopathicMembranous Nephropathy,IMN)约

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