广西地区HPV感染及其基因型分析

发布时间：2018-02-03 02:43

本文关键词： 人乳头瘤病毒基因型分布感染率　出处：《医学研究生学报》2017年12期 　论文类型：期刊论文

【摘要】：目的人乳头瘤病毒(HPV)相关疾病的发病率逐年上升。文中研究广西地区HPV感染及其基因型别分布情况及趋势。方法回顾性分析2010年5月至2017年3月于广西壮族自治区人民医院门诊、住院患者以及体检人群共15 774例。采集脱落细胞或皮损处分泌物拭子,应用基因扩增及反向斑点杂交技术对HPV基因型别进行检测。结果15 774例研究对象中检出HPV感染者6080例,HPV总感染率为38.54%。单一型别感染率和多重型别感染率分别为25.60%(4038/15 774)和12.95%(2042/15 774)。其中HPV 6(10.54%,1663/15 774)、HPV52(3.91%,616/15 774)、HPV16(2.16%,340/15 774)、HPV11(2.14%,338/15 774)和HPV58型(2.00%,316/15 774)是单一型别感染的主要型别;在2042例多重感染者中,HPV 52+53(4.26%,87/2042)和52+58型(3.23%,66/2042)是检出率最高的多重感染型别组合,其次为HPV 16+43(2.40%,49/2042)和16+52(2.30%,47/2042)。前6位高危型HPV分别为52、16、58、51、53和18型,6种HPV总感染率为26.77%(4222/15 774,95%CI=26.08~27.46);而低危型HPV分别为6、11和43型,3种HPV总感染率为27.77%(4380/15 774,95%CI=27.07~28.47)。结论 HPV6、52、16、11、58和18是广西地区HPV感染的主要基因型别,HPV 52+53、52+58型是主要的多重感染组合,其中52型是广西地区主要的高危HPV基因型别。
[Abstract]:Objective Human papillomavirus (HPV). The incidence of related diseases increased year by year. The distribution and trend of HPV infection and its genotypes in Guangxi were studied retrospectively from May 2010 to March 2017 in Guangxi Zhuang Autonomous region. People's Hospital outpatient. A total of 15 774 cases of inpatients and physical examination were collected from exfoliated cells or skin samples. Genotypes of HPV were detected by gene amplification and reverse dot blot hybridization. Results 6080 cases of HPV infection were detected in 15 774 subjects. The total infection rate of HPV was 38.54.The single type infection rate and the multiple type infection rate were 25.60 and 12.95, respectively. 2042/15 774% of them were HPV. 1663/15 774 HPV52 / 3.91; 616 / 15 774; HPV16 / 2.16; 340 / 15774). HPV11 / 2.14) and HPV58 type 2.00 / 3.16 / 15774) are the main types of single type infection. In 2042 cases of multiple infections, HPV52 53 / 4.26 / 2042% and 5258 type were 3.23%. 66 / 2042) was the highest detection rate of multiple infections, followed by HPV 16 432.40 (49 / 2042) and 16 52% (2.30%). The total infection rate of the first six high risk HPV types were 52165851C 53 and 18 HPV, respectively. The total infection rate was 26.77 / 4222 / 15 774. The total infection rate was 4222% / 15 774 in the first 6 high risk type HPV, and the total infection rate was 26.77% / 4222% / 15 774 respectively. 95. CII 26.08 and 27.46; The total infection rate of low risk HPV was 6 / 11 and 43 / 3 respectively, and the total infection rate of HPV was 27. 7780 / 15 774. Conclusion HPV6 5216A1158 and HPV18 are the major genotypes of HPV infection in Guangxi. Type 52 58 is the main multiple infection combination, in which 52 type is the main high risk HPV genotype in Guangxi.
【作者单位】：广西壮族自治区人民医院检验科;南京中医药大学第三附属医院病理科;
【基金】：广西科学研究与技术开发计划(桂科攻1598013-3)
【分类号】：R737.33
【正文快照】： 0引言人乳头状瘤病毒(human papilloma virus,HPV)是一类无包膜、环状、双链DNA的嗜上皮性病毒,能引起人体皮肤、黏膜及鳞状上皮增殖。目前已报道的HPV型别超过200种,其中约40种与生殖系统感染相关[1]。根据其致癌潜能,可分为低危型和高危型两大类[2]。低危型主要引起生殖道肛

【相似文献】