注意缺陷多动障碍转换功能与NRXN1基因的关联研究

发布时间：2018-02-12 20:07

本文关键词： 注意缺陷多动障碍 NRXN基因转换功能关联研究　出处：《中国心理卫生杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨注意缺陷多动障碍(ADHD)转换功能与NRXN1基因的关联。方法:顺序纳入符合美国精神障碍诊断与统计手册第4版(DSM-IV)ADHD诊断标准的ADHD儿童756例和年龄匹配的正常对照儿童133例。采用TMT连线测试(Trail Making Test)记录被试者转换功能各指标,包括数字连线时间、数字连线错误次数、数字字母连线时间和数字字母连线错误次数。选择NRXN1基因的两个单核苷酸多态性(rs1592728和rs4971652)位点,利用Sequenom基因分型平台进行基因型检测。在全部ADHD病例儿童和正常对照采用多重线性回归分析基因型对ADHD转换功能的影响因素,其次,分别在ADHD组和对照组中采用多重线性回归分层分析转换功能与基因型之间的关联。结果:多重线性回归显示转换功能与年龄(β=0.42,P0.001)、智商(β=0.34,P0.001)、罹患ADHD(β=0.08,P=0.004)和rs4971652GG基因型(β=0.06,P=0.039)负向关联;ADHD组转换功能与年龄(β=0.46,P0.001)、智商(β=0.32,P0.001)、rs4971652的GG基因型(β=0.07,P=0.018)负向关联,与ADHD亚型(β=0.06,P=0.033)正向关联,ADHD-I型比ADHD-C型患儿受损严重;对照组转换功能与年龄(β=0.25,P=0.002)、智商(β=0.40,P0.001)负向关联。结论:ADHD患儿转换功能可能与NRXN1基因SNPs存在关联,GG基因型患者转换功能受损相对轻。
[Abstract]:Objective: to investigate the association between ADHD conversion function and NRXN1 gene in attention deficit hyperactivity disorder (ADHD). Methods: 756 children with ADHD and normal age-matched children who met the diagnostic criteria of DSM-IVD ADHD in the fourth edition of the American Handbook for the diagnosis and Statistics of Mental Disorder were included in the sequence. In the control group, 133 children were tested with TMT Making test to record each index of the subjects' conversion function. Including digital connection time, number of digital connection errors, digital alphanumeric connection time and number of alphanumeric connection errors. Two single nucleotide polymorphisms of the NRXN1 gene, rs1592728 and rs4971652) were selected. Genotypes were detected by Sequenom genotyping platform. Multiplex linear regression analysis was used to analyze the influence factors of genotype on ADHD conversion function in all children with ADHD and normal controls. Multiple linear regression analysis was used to analyze the correlation between conversion function and genotype in ADHD group and control group respectively. Results: multiple linear regression analysis showed that conversion function and age (尾 -0.42), intelligence quotient (尾 = 0.34), ADHD (尾 -0.08) and rs4971652GG genotype (尾 0.06P ~ (0.039)) were negatively correlated with age (尾 = 0.42), IQ (尾 = 0.34), and rs4971652GG genotype (尾 0.06 P ~ (0.039)). The conversion function of ADHD group was negatively correlated with the GG genotype of age (尾 -0.46, P 0.001), IQ (尾 -0.32, P 0.001, rs4971652) (尾 -0. 07, P 0. 018, P 0. 018), and a negative correlation between the GG genotype and age (尾 -0.36, P 0. 001, P 0. 001). The positive association of ADHD-I with ADHD subtype was more serious than that of ADHD-C, and the transition function of control group was negatively correlated with age (尾 -0.25) and intelligence quotient (尾 _ (0.40) P 0.001). Conclusion there may be a correlation between the conversion function of children with ADHD and SNPs of NRXN1 gene, and the impairment of conversion function in patients with GG genotype is relatively slight.
【作者单位】：北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学);
【基金】：国家自然科学基金(81671358);国家自然科学基金(81471381) 国家重点基础研究发展计划项目(973计划)(2014CB846100)
【分类号】：R749.94

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