MDR1 C3435T基因多态性与胃溃疡患者治疗相关性分析

发布时间：2018-03-07 12:46

本文选题：胃溃疡　切入点：MDR　出处：《贵州医药》2016年11期 　论文类型：期刊论文

【摘要】：目的分析MDR1C3435T基因多态性与胃溃疡患者治疗的相关性。方法回顾性分析2010年10月至2015年10月来我院就诊的胃溃疡患者共80名,其中Hp阳性患者47例,另选取80例健康体检者作为对照组,测定两组入选对象MDR1C3435T基因多态性,比较不同基因型胃溃疡患者治疗后Hp阳性率和耐药率。结果观察组(Hp阳性)患者3435TT基因型频率和T等位基因频率均明显高于观察组(Hp阴性)和对照组(P0.05);观察组(Hp阴性)患者3435TT基因型频率和T等位基因频率亦均明显高于对照组(P0.05)。治疗后3435TT基因型患者Hp阳性率和耐药率均明显高于C3435T和CC3435基因型患者(P0.05)。结论 MDR1C3435T基因多态性与胃溃疡患者的治疗具有相关性,3435TT基因型患者较难根除Hp,耐药性较强。
[Abstract]:Objective to analyze the relationship between the polymorphism of MDR1C3435T gene and the treatment of gastric ulcer. Methods from October 2010 to October 2015, there were 80 patients with gastric ulcer, 47 of whom were HP positive. In addition, 80 healthy persons were selected as control group, and the polymorphism of MDR1C3435T gene was measured in the two groups. Results the frequency of 3435TT genotype and T allele in patients with different genotypes of gastric ulcer after treatment were significantly higher than those in control group (P 0.05). The frequency of 3435TT genotype and T allele were significantly higher in patients with 3435TT than those in control group (P 0.05). The HP positive rate and drug resistance rate in patients with 3435TT genotype after treatment were significantly higher than those in patients with C3435T and CC3435 genotypes (P 0.05). Conclusion the polymorphism of MDR1C3435T gene in patients with C3435TT genotype is higher than that in patients with C3435T genotype and CC3435 genotype. The treatment of gastric ulcer patients is more difficult to eradicate HpT and drug resistance is stronger in the patients with allele 3435TT genotype.
【作者单位】：常州市中医医院消化内科;
【分类号】：R573.1

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