武汉地区汉族人群纤溶酶原激活物抑制物基因多态性分析

发布时间：2018-03-13 16:23

本文选题：纤溶酶原激活物抑制物-　切入点：武汉市　出处：《山东医药》2017年31期 　论文类型：期刊论文

【摘要】：目的分析武汉地区汉族人群纤溶酶原激活物抑制物-1(PAI-1)基因多态性。方法采用荧光染色原位杂交技术检测1 533例(男728例、女805例)武汉汉族人群PAI-1-675基因多态性,并结合文献比较不同地区及种族PAI-1-675位点等位基因、基因型频率。结果武汉地区汉族人群PAI-1-675位点等位基因及基因型分布不具有性别差异(P0.05)。武汉地区汉族人群4G等位基因频率低于广州地区,4G/4G基因型频率低于广州、长沙地区,4G/5G基因型频率高于广州、长沙地区,P均0.01。武汉汉族人4G等位基因频率高于加纳人、土耳其人、印度人、日本人、南非人;4G/4G基因型频率高于加纳人、土耳其人、印度人、马其顿人、日本人、南非人;4G/5G基因型频率高于加纳人、土耳其人、印度人、日本人、南非人,低于马其顿人;P均0.01。结论武汉地区汉族人群PAI-1基因多态性有地区、种族差异,但无性别差异。
[Abstract]:Objective to analyze the polymorphism of plasminogen activator inhibitor (PAI-1) gene in Wuhan Han population. Methods the polymorphism of PAI-1-675 gene in 1 533 cases (728 males and 805 females) was detected by fluorescence staining in situ hybridization. The alleles of PAI-1-675 loci in different regions and races were compared with the literature. Results there was no gender difference in PAI-1-675 alleles and genotype distribution in Wuhan Han population. The frequency of 4G allele in Wuhan Han population was lower than that in Guangzhou, and the frequency of 4G genotype in Wuhan Han population was lower than that in Guangzhou. The frequency of 4G / 5G genotype in Changsha is higher than that in Guangzhou, and the frequency of 4G allele in Wuhan Han nationality is higher than that in Ghanaian, Turkish, Indian, Japanese, South African, South African, and the frequency of 4G / 5G genotype is higher than that of Ghanaian, Turkish, Indian, etc. The frequency of 4G / 5G genotype in Macedonians, Japanese and South Africans was higher than that in Ghanaians, Turks, Indians, Japanese, South Africans and Macedonians (P < 0.01). But there is no gender difference.
【作者单位】：武汉市第一医院;
【分类号】：R543.6

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