重症肌无力与CTLA-4基因多态性的Meta分析

发布时间：2018-03-22 06:06

本文选题：重症肌无力　切入点：细胞毒性T淋巴细胞相关抗原　出处：《安徽医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨细胞毒性T淋巴细胞相关抗原-4(CTLA-4)基因多位点单核苷酸多态性(SNP)与重症肌无力(MG)易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普、PubMed、Cochrane Library、OvidSP、Wiley Online Library、EBSCO、Elsevier Science Direct、Springer Link数据库检索CTLA-4基因与MG相关的病例对照研究,利用Rev Man 5.3软件计算其基因型和等位基因与MG的关联性。结果共纳入10篇文献,将MG分为胸腺瘤型MG(TAMG)、胸腺增生型MG(THMG)、自身免疫性MG(AIMG)。Meta分析显示携有CTLA-4基因rs231775 G等位基因的人群罹患MG的风险增高(OR=1.55,95%CI:1.13~2.12,P=0.006)、罹患AIMG的风险增高(OR=1.39,95%CI:1.09~1.77,P=0.007),携有rs733618 CC基因型的人群罹患AIMG的风险增高(OR=3.28,95%CI:1.89~5.70,P0.001),携有rs733618 C等位基因的人群罹患AIMG的风险增高(OR=1.76,95%CI:1.30~2.37,P0.001)。结论 CTLA-4基因rs231775 G等位基因、rs733618CC基因型和C等位基因与AIMG易感性之间有关联性。
[Abstract]:Objective to investigate the association between multilocus single nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte associated antigen (CTLA-4) gene and susceptibility to myasthenia gravis (MG). The Rev Man 5.3 software was used to calculate the correlation between the genotype and allele of CTLA-4 gene and MG. The MG was divided into thymoma type, thymic hyperplasia type, and thymic proliferative type. Autoimmune MG(AIMG).Meta analysis showed that the population with the rs231775 G allele of CTLA-4 gene had an increased risk of developing MG. The risk of developing AIMG was increased in the population with rs733618 CC genotype, and the risk of AIMG was increased in the population with rs733618 CC genotype. The risk of AIMG in the population with the rs733618 C allele was increased. Conclusion the CTLA-4 G allele rs231775 G allele rs733618CC genotype and C allele are associated with the susceptibility to AIMG.
【作者单位】：安徽医科大学附属省立医院神经内科;安徽医科大学附属阜阳医院骨科;安徽省肿瘤医院(安徽省立医院西区)急诊内科;
【基金】：安徽省卫生厅医学科研课题(编号:13zc032)
【分类号】：R746.1

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