铅神经毒性相关基因多态性的研究进展

发布时间：2018-03-24 03:04

本文选题：铅　切入点：神经毒性　出处：《环境与健康杂志》2017年02期

【摘要】：长期铅暴露可对人体多个器官和系统造成损伤,其神经毒性效应尤为突出。在相同的铅暴露水平下,因遗传易感性的个体差异,不同人群的铅中毒损伤程度和临床症状不尽相同。该差异可能与δ-氨基乙酰丙酸脱水酶(Deltaaminolevulinic acid dehydratase,ALAD)、维生素D受体(Vitamin D receptor,VDR)、N-甲基D-天冬氨酸受体(N-methyl-Daspartate receptor,NMDAR)及多巴胺受体D2(Dopamine receptor D2,DRD2)等基因多态性有关。该文回顾近年来国内外铅神经毒性相关基因多态性的研究,对铅的神经毒性、相关基因多态性与铅神经毒性的关系进行综述。
[Abstract]:Long-term lead exposure can cause damage to multiple organs and systems of the human body, and its neurotoxic effects are particularly pronounced. At the same level of lead exposure, individual differences in genetic susceptibility are associated with individual differences in genetic susceptibility. The degree of injury and clinical symptoms of lead poisoning are different among different populations. This difference may be similar to that of Deltaaminolevulinic acid dehydratase, Vitamin D receptor, N-methyl-Daspartate receptor NMDAR and dopamine receptor D2(Dopamine receptor D2DRD2). This article reviews the recent studies on the polymorphisms of lead neurotoxic genes at home and abroad. The relationship between lead neurotoxicity, related gene polymorphism and lead neurotoxicity was reviewed.
【作者单位】：中南大学湘雅医院肿瘤科;中南大学湘雅医院耳鼻咽喉头颈外科;
【基金】：国家自然科学基金青年基金(81300819);国家自然科学基金面上项目(81170912) 国家重大科学研究计划(2014CB943003)
【分类号】：R114

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