胱硫醚β-合成酶G919A基因多态性与原发性高血压关系的meta分析

发布时间：2018-03-24 04:27

本文选题：胱硫醚β-合成酶　切入点：原发性高血压　出处：《心脑血管病防治》2016年06期

【摘要】：目的综合评估胱硫醚β-合成酶(CBS)基因G919A多态性与原发性高血压(EH)发生风险的关系。方法全面检索Pub Med、Embase、Medline、万方数据库、中国知网(CNKI)、维普资讯,收集CBS基因G919A多态性与EH发生关系的病例对照研究,优势比(OR)及95%可信区间(CI)评估关联强度,应用Rev Man5.3软件对纳入研究进行异质性检验和效应值OR合并,漏斗图评价发表性偏倚;敏感度分析过程,分别以固定效应模型和随机效应模型合并OR值,以评估结果的稳定性。结果共纳入4篇文献6组病例-对照研究,共累计EH组患者1147例,健康对照组1138例,根据异质性检验结果选取固定效应模型或随机效应模型合并数据。Meta分析结果显示:CBS基因919纯合子模型(AA vs GG)、杂合子模型(GA vs GG)、显性模型(AA+GA vs GG)、隐性模型(AA vs GG+GA)和基因频率(A vs G)与EH关系的合并OR(95%CI)分别为3.03(1.95~4.72)、1.49(1.10~2.02)、1.61(1.23~2.10)、2.65(1.26~5.57)和1.55(1.35~1.79),均P0.01。漏斗图未检测出显著的发表性偏倚。结论目前Meta分析表明CBS基因G919A多态性与EH发病相关联,尤其是在中国人群。
[Abstract]:Objective to evaluate the relationship between the G919A polymorphism of cystathithione 尾 -synthase (CBS) gene and the risk of essential hypertension (EH). A case-control study on the relationship between G919A polymorphism of CBS gene and EH was conducted. The odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association strength. Heterogeneity test and OR combination were performed by Rev Man5.3 software. In order to evaluate the stability of the results, OR value was combined with fixed effect model and random effect model in the process of sensitivity analysis. The results were included in 6 groups of case-control studies in 4 literature. There were 1147 patients in EH group and 1138 healthy control group. According to heterogeneity test results, fixed effect model or random effect model combined with data. Meta-analysis results showed that the homozygote model of 1: CBS gene 919 was AA vs GG, heterozygote model was GA vs GGG, dominant model was AA GA vs GGG, recessive model AA vs GG, recessive model AA vs GG. The combined OR95 CII of the relationship between GA) and gene frequency A vs G) and EH were 3.031.95 / 4.72A 1.491.102.02U 1.232.102.101.265.57) and 1.551.351.351.79 respectively. No significant published bias was detected on funnel map. Conclusion the present Meta analysis shows that the G919A polymorphism of CBS gene is associated with the pathogenesis of EH, and the relationship between G919A polymorphism and EH is not found in the study of the relationship between G919A polymorphism of CBS gene and the incidence of EH, and the relationship between G919A polymorphism and EH is also found in G919A gene analysis, and there is no significant association between G919A polymorphism and EH. Especially in China.
【作者单位】：吉林大学第一医院;
【分类号】：R544.11

【相似文献】