基质金属蛋白酶基因多态性与慢性阻塞性肺疾病患病风险的Meta分析

发布时间：2018-04-01 11:17

本文选题：Meta分析　切入点：基质金属蛋白酶-　出处：《南京医科大学学报(自然科学版)》2017年10期

【摘要】：目的:运用Meta分析的方法综合评价基质金属蛋白酶-9(matrix metalloproteinase-9)-1562C/T(rs3918242)基因多态性与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)易感性的关系。方法:通过计算机检索Pub Med、EMBASE、FMJS和CNKI数据库,并结合文献追溯、手工检索等方法 ,收集所有符合纳入标准的病例对照研究。应用Meta分析合并MMP-9-1562C/T多态性与COPD易感性关系的OR值,并进行亚组分析、敏感性分析和文献的发表偏倚检验。结果:本次Meta分析共纳入13篇文献,累计病例2 295例,对照2 539例。结果显示,MMP-9-1562C/T多态性与COPD患病风险有关(显性遗传模型:OR=1.40,95%CI:1.03~1.91,P=0.03);按人种行亚组分析,结果表明MMP-9-1562C/T多态性可增加亚洲人COPD患病风险(显性遗传模型:OR=1.80,95%CI:1.04~3.11,P=0.04)。本研究所纳入的研究均可靠且没有发表偏倚。结论:本Meta分析结果表明,MMP-9-1562C/T多态性与COPD的易感性有关,并以显性遗传模型发挥作用。
[Abstract]:Objective: to evaluate the relationship between the polymorphism of matrix metalloproteinase-9 matrix metalloproteinase-9 (-1562C / Trs3918242) gene and the susceptibility of chronic obstructive pulmonary disease (obstructive) by Meta. Methods: the database of Pub Medus EMBASEFMJS and CNKI was searched by computer, and the literature was reviewed. Methods such as manual retrieval were used to collect all case-control studies that met the inclusion criteria. Meta analysis combined with MMP-9-1562C/T polymorphism was used to analyze the OR value of the susceptibility to COPD, and subgroup analysis was performed. Sensitivity analysis and publication bias test. Results: 13 articles were included in this Meta analysis, with a total of 2 295 cases. The results showed that MMP-9-1562C / T polymorphism was associated with the risk of COPD. The results showed that MMP-9-1562C/T polymorphism could increase the risk of COPD in Asian population (the dominant genetic model: 1. 80 / 95 CI: 1.04 / 3.11P0.04). All the studies included in this study were based on and had no published bias. Conclusion: the results of this Meta analysis showed that MMP-9-1562 C / T polymorphism was associated with the susceptibility to COPD. And the dominant genetic model was used to play a role.
【作者单位】：河北医科大学临床医学系;河北医科大学第四医院分子生物学研究室;
【基金】：河北省杰出青年科学基金培育项目(H2015206471)
【分类号】：R563.9

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