乙醛脱氢酶2基因多态性与早发冠心病的相关性研究

发布时间：2018-04-08 20:24

  本文选题：早发冠心病　切入点：乙醛脱氢酶　出处：《解放军医学杂志》2017年12期

【摘要】：目的探讨中国汉族人群中,乙醛脱氢酶2(ALDH2)基因多态性与早发冠心病之间的关系。方法本研究共纳入505例患者,根据冠脉造影结果确诊冠心病患者375例及非冠心病患者130例,其中冠心病患者又分为早发冠心病组150例(男55岁,女65岁)和晚发冠心病组225例(男≥55岁,女≥65岁)。另外,将505例患者根据饮酒后是否面红分为面红组135例和非面红组370例,根据是否有习惯性饮酒分为饮酒习惯组189例和无饮酒习惯组316例。通过Sanger测序的方法对ALDH2基因的多态性进行分析。结果 ALDH2基因型分布在早发冠心病组与晚发冠心病组间,以及冠心病组与非冠心病组间差异均无统计学意义(P0.05),logistics回归校正性别、年龄、抽烟、饮酒、体重指数(BMI)、高血压、糖尿病、高脂血症、冠心病家族史等因素后,ALDH2基因不是早发冠心病和冠心病的易感因素(P=0.729,OR=1.098,95%CI 0.648~1.859;P=0.581,OR=1.156,95%CI 0.692~1.930)。ALDH2突变型(GA+AA)发生率在饮酒面红组中(67.4%)明显高于非面红组(10.5%,P0.01),在无饮酒习惯组中(29.7%)高于有饮酒习惯组(19.1%,P0.01)。结论 ALDH2基因多态性不是中国汉族人群中早发冠心病及冠心病发病的危险因素,饮酒面红与ALDH2突变型基因有关。
[Abstract]:Objective to investigate the association between aldehydes dehydrogenase (ALDH2) gene polymorphism and premature coronary heart disease (CHD) in Chinese Han population.Methods A total of 505 patients were enrolled in this study. 375 patients with coronary heart disease and 130 patients with non-coronary heart disease were diagnosed by coronary angiography. The patients with coronary heart disease were divided into early onset coronary heart disease group (150 cases, male 55 years old).There were 225 cases of late coronary heart disease (male 鈮，

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