P-选择素基因S290N和P-选择素糖蛋白配体-1基因M62I多态性与缺血性脑梗死临床关联性研究

发布时间：2018-04-25 23:34

本文选题：P-选择素 + P-选择素糖蛋白配体-　；参考：《临床神经病学杂志》2017年01期

【摘要】：目的探讨P-选择素(SELP)基因S290N和P-选择素糖蛋白配体-1(PSGL-1)基因M62I多态性与缺血性脑梗死的关系。方法选取148例缺血性脑梗死患者作为脑梗死组,并分为大动脉粥样硬化性(LAA)亚组、心源性脑栓塞(CE)亚组和小动脉闭塞性(SAO)亚组;88例正常人群作为正常对照组。运用基因测序方法检测所有受试者SELP基因S290N和PSGL-1基因M62I的基因多态性。结果与正常对照组比较,脑梗死组及其亚组S290N基因型和等位基因频率差异无统计学意义(均P0.05);脑梗死组M62I基因型和等位基因频率差异有统计学意义(均P0.01);LAA亚组M62I基因型差异无统计学意义(χ~2=5.889,P=0.053),但等位基因频率差异有统计学意义(χ~2=6.156,P=0.021);CE亚组基因型和等位基因频率差异均无统计学意义(χ~2=1.693,P=0.429;χ~2=1.372,P=0.238);SAO亚组基因型和等位基因频率差异均有统计学意义(χ~2=12.572,P=0.002;χ~2=8.736,P=0.004)。S290N与缺血性脑梗死风险无相关性(均P0.05)。M62I显性模型和超显性模型与缺血性脑梗死风险有相关性(OR=2.662,95%CI:1.531~4.630,P=0.000;OR=0.392,95%CI:0.219~0.701,P=0.001),而隐性模型和加性模型与缺血性脑梗死风险无相关性(OR=1.428,95%CI:0.528~3.862,P=0.630;OR=2.121,95%CI:0.766~5.872,P=0.156)。结论 PSGL-1基因M62I多态性与缺血性脑梗死之间具有相关性。
[Abstract]:Objective to investigate the relationship between P- selectin S290N and P- selectin glycoprotein ligand-1 PSGL-1) gene M62I polymorphism and ischemic cerebral infarction (ICI). Methods 148 patients with ischemic cerebral infarction were selected as cerebral infarction group and divided into three subgroups: Atherosclerotic subgroup, cardiac cerebral embolism (CEE) subgroup and arteriolar occlusive SAO subgroup (88 normal controls). Gene polymorphisms of SELP gene S290N and PSGL-1 gene M62I were detected by gene sequencing. Results compared with the normal control group, There was no significant difference in the frequency of S290N genotype and allele between cerebral infarction group and its subgroup (all P 0.05), but there was no significant difference in M62I genotype and allele frequency in cerebral infarction group (P 0.01). The allele frequencies were statistically significant (蠂 2 6.156P 0.021) and allele frequencies in CE subgroup were not significantly different (蠂 2 / 2 / 1.693P = 0.429; 蠂 2 / 1.372P 0.238SAO / P = 0.238A / P = 0.002; 蠂 28.738.6P 0.004P 0.004N, P = 0.290N, P = 0.238SAO, respectively) (蠂 212.572P = 0.002; 蠂 28.738.76.6P 0.004P 0.004N) and the risk of ischemic cerebral infarction (蠂 ~ 28.738.6P 0.004N) and the risk of ischemic cerebral infarction (蠂 ~ 28.736.6N / P 0.004N / P _ 290N / P _ (290N) respectively (蠂 ~ 212.572P _ (0.002). There was no correlation between the P0.05).M62I dominant model and the superdominance model and the risk of ischemic cerebral infarction. There was no correlation between the P0.05).M62I dominant model and the risk of ischemic cerebral infarction. There was no correlation between the recessive model and the additive model and the risk of ischemic cerebral infarction. There was no correlation between the two models and the risk of ischemic cerebral infarction. There was no correlation between the model and the risk of ischemic cerebral infarction, but there was no correlation between the recessive model and the additive model and the risk of ischemic cerebral infarction. There was no correlation between the model and the risk of ischemic cerebral infarction, but there was no correlation between the implicit model and the additive model and the risk of ischemic cerebral infarction, and there was no correlation between the recessive model and the additive model and the risk of ischemic cerebral infarction. Conclusion PSGL-1 gene M 62 I polymorphism is associated with ischemic cerebral infarction.
【作者单位】：华中科技大学同济医学院附属荆州医院检验医学部;华中科技大学同济医学院附属荆州医院神经内科;
【分类号】：R743.33

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