基于Oncomine荟萃分析HJURP基因在头颈部癌中的表达和预后研究

发布时间：2018-05-07 02:26

本文选题：头颈部癌 + Oncomine　；参考：《重庆医科大学学报》2017年09期

【摘要】：目的:阐述HJURP基因(holliday junction recognition protein)在头颈部癌及正常组织中的表达及对预后影响。方法:挖掘Oncomine数据库中头颈部癌HJURP基因相关数据,并结合ArrayExpress中芯片数据集进行生存分析。结果:Oncomine数据库中,针对不同癌症,HJURP基因癌组织/正常组织表达量分析共有383个结果,其中在癌组织中显著高表达的有125个结果,低表达的仅18个结果。有13个数据集共27个分析涉及HJURP在头颈部癌组织/正常组织中的表达,其中8个分析结果显示HJURP在头颈部癌组织中显著高表达,仅一个分析结果显示其在癌组织中低表达。通过对ArrayExpress中E-TABM-302芯片数据集生存分析表明,HJURP的表达量与预后存在明显负相关性,即HJURP表达量越高,总体生存越差。结论:通过整合Oncomine芯片数据和生存相关芯片数据,首次提出HJURP在头颈部癌中高表达且对预后有不良影响,为肿瘤药物的开发提供了潜在靶点。
[Abstract]:Objective: to investigate the expression of HJURP gene junction recognition protein in head and neck cancer and normal tissues and its influence on prognosis. Methods: the related data of HJURP gene of head and neck cancer were mined from Oncomine database, and survival analysis was carried out with ArrayExpress data set. Results in the Oncomine database, there were 383 results of HJURP gene expression in cancer tissues / normal tissues. Among them, 125 results were significantly overexpressed in cancer tissues, and only 18 results were low expression. There were 27 data sets involving HJURP expression in head and neck carcinomas / normal tissues. Eight of them showed that HJURP expression was significantly higher in head and neck cancer tissues, and only one analysis showed that HJURP expression was low in head and neck cancer tissues. The survival analysis of E-TABM-302 data sets in ArrayExpress showed that there was a negative correlation between the expression of HJURP and prognosis, that is, the higher the expression of HJURP, the worse the overall survival. Conclusion: by integrating the data of Oncomine chip and survival chip, it is the first time to propose that the high expression of HJURP in head and neck cancer has adverse effect on prognosis, which provides a potential target for the development of tumor drugs.
【作者单位】：重庆医科大学附属第一医院口腔科;重庆市人民医院口腔科;重庆市人民医院急诊科;
【分类号】：R739.91

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