IL-6基因rs1800796多态性与小儿热性惊厥易感性的Meta分析

发布时间：2018-05-07 10:06

本文选题：白细胞介素- + 多态性　；参考：《重庆医学》2017年15期

【摘要】：目的系统评价白细胞介素-6(IL-6)基因-572C/G(rs1800796)多态性与小儿热性惊厥易感性的关系。方法计算机检索PubMed,Web of Science,Embase,Cochrane Library,中国知网(CNKI),万方,维普(VIP)及中国生物医学文献数据库(CBM),收集发表的IL-6基因rs1800796多态性与小儿热性惊厥易感性的相关文献,以OR及其95%CI为合并效应量,采用RevMan 5.2软件进行统计学分析,以STATA12.0软件进行发表偏倚分析。结果根据纳入及排除标准,本研究共纳入7项独立的病例-对照研究,累计病例516例,对照528例。结果显示IL-6基因-572C/G(rs1800796)多态性与小儿热性惊厥易感性之间具有显著关联(GG+CGvs.CC:OR=2.22,P=0.05;Gvs.C:OR=2.44,P0.01;GGvs.CC:OR=3.69,P=0.03;GGvs.CG+CC:OR=3.43,P0.01)。根据可能的重要的混杂因素进行亚组分析,结果显示,在中国人群中,该基因多态性与小儿热性惊厥发病风险具有显著关联(GG+CGvs.CC:OR=3.32,P0.01;Gvs.C:OR=3.23,P0.01;GGvs.CC:OR=7.27,P0.01;GG vs.CG+CC:OR=5.17,P0.01:CGvs.CC:OR=2.56,P=0.02)。而在其他人群中除在隐形模型(GGvs.CG+CC:OR=2.40,P0.01)外,其他遗传模型均未显示明显相关性。根据FS诊断标准进行亚组分析,结果发现,依据中国标准进行诊断时,该基因多态性与小儿热性惊厥发病具有显著相关性(GG+CGvs.CC:OR=4.57,P0.01;Gvs.C:OR=4.36,P0.01;GG vs.CC:OR=12.75,P0.01;GG vs.CG+CC:OR=8.60,P0.01:CG vs.CC:OR=3.40,P0.01)。结论IL-6基因-572C/G(rs1800796)多态性可能与小儿FS易感性有关,G等位基因可能是FS发病的危险因子。
[Abstract]:Objective to systematically evaluate the relationship between the polymorphism of interleukin -6 (IL-6) gene -572C/G (rs1800796) and the susceptibility to febrile convulsion in children. Methods a computer was used to retrieve PubMed, Web of Science, Embase, Cochrane Library, Chinese know net (CNKI), Wanfang, VP and Chinese biomedical literature database. The related literature of the susceptibility to febrile convulsion in children, using OR and its 95%CI as the combined effect, using RevMan 5.2 software for statistical analysis, and using STATA12.0 software for publication bias analysis. Results according to the inclusion and exclusion criteria, this study included 7 independent case control studies, 516 cases of cumulative cases, and 528 cases of control. There was a significant association between the IL-6 gene -572C/G (rs1800796) polymorphism and the susceptibility to febrile convulsion in children (GG+CGvs.CC:OR=2.22, P=0.05; Gvs.C:OR=2.44, P0.01; GGvs.CC:OR=3.69, P=0.03; GGvs.CG+CC:OR=3.43, P0.01). Subgroup analysis based on possible major confounding factors showed that the gene polymorphism was found in Chinese population. There is a significant association with the risk of febrile convulsion in children (GG+CGvs.CC:OR=3.32, P0.01; Gvs.C:OR=3.23, P0.01; GGvs.CC:OR=7.27, P0.01; GG vs.CG+CC:OR=5.17, P0.01:CGvs.CC:OR=2.56, P=0.02). But in other populations, except for the stealth model (GGvs.CG+CC:OR=2.40, P0.01), other genetic models have not shown significant correlation. The subgroup analysis showed that there was a significant correlation between the polymorphism of the gene and the onset of febrile convulsion in children (GG+CGvs.CC:OR=4.57, P0.01; Gvs.C:OR=4.36, P0.01; GG vs.CC:OR=12.75, P0.01; GG vs.CG+CC:OR=8.60, P0.01:CG vs.CC:OR=3.40). Sex may be associated with susceptibility to FS in children, and G allele may be a risk factor for FS.

【作者单位】：湖北省十堰市妇幼保健院儿童保健中心;
【分类号】：R720.597

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