汉族人系统性红斑狼疮和狼疮肾炎与IL-22受体基因多态性的关系

发布时间：2018-05-15 13:31

本文选题：系统性红斑狼疮 + IL-受体　；参考：《中国现代医学杂志》2017年09期

【摘要】：目的对汉族人群系统性红斑狼疮患者白细胞介素22(IL-22)受体基因多态性进行研究,探讨其与系统性红斑狼疮和狼疮肾炎的关系。方法选取2012年1月-2016年6月吉林大学第一医院系统性红斑狼疮患者360例和健康者360例作为研究对象,将其分为A组(系统性红斑狼疮组)和B组(对照组);系统性红斑狼疮患者分为C组(狼疮肾炎组)和D组(无狼疮肾炎组)。观察IL-22R1基因rs3795299位点基因型和等位基因频率与系统性红斑狼疮、狼疮肾炎及系统性红斑狼疮临床特点的关系。结果 A组与B组IL-22R1基因rs3795299位点基因型和等位基因频率比较,差异无统计学意义(P0.05)。C组患者GG基因型所占比例高于D组患者(P0.05),CG和CC基因型所占比例低于D组患者(P0.05);C组患者等位基因G频率低于D组(P0.05),等位基因C频率高于D组(P0.05)。IL-22R1基因rs3795299位点等位基因频率在系统性红斑狼疮患者有关节炎、面部红斑、光敏感和口腔溃疡患者中的分布与无关节炎、面部红斑、光敏感和口腔溃疡患者中的分布不同,差异有统计学意义(P0.05)。结论在中国汉族人群中,IL-22R1基因rs3795299位点基因多态性与系统性红斑狼疮的易感性无关,与狼疮肾炎的易感性有关,与系统性红斑狼疮的临床特点相关。
[Abstract]:Objective to investigate the polymorphism of interleukin-22 (IL-22) receptor gene in patients with systemic lupus erythematosus (SLE) and its relationship with systemic lupus erythematosus (SLE) and lupus nephritis (SLE). Methods 360 patients with systemic lupus erythematosus and 360 healthy subjects were selected from January 2012 to June 2016. Group A (systemic lupus erythematosus) and group B (control group) were divided into group C (lupus nephritis group) and group D (no lupus nephritis group). To investigate the relationship between rs3795299 genotype and allele frequency of IL-22R1 gene and clinical features of systemic lupus erythematosus, lupus nephritis and systemic lupus erythematosus. Results the genotypes and allelic frequencies of IL-22R1 rs3795299 loci in group A and B were compared. There was no significant difference in the percentage of GG genotypes in patients with P0.05U. C group compared with those in group D patients. The G frequency of allele G was lower in group C than that in group D, and the frequency of allele C was higher than that in group D (P 0.05N. IL-22R1). The allele frequency of rs3795299 locus was found in patients with systemic lupus erythematosus (SLE). The distribution of erythema, light sensitivity and oral ulcers was different from that in patients without arthritis, erythema, light sensitivity and oral ulcers, and the difference was statistically significant (P 0.05). Conclusion the polymorphism of rs3795299 locus of IL-22R1 gene is not associated with the susceptibility of systemic lupus erythematosus, but associated with the susceptibility of lupus nephritis and the clinical features of systemic lupus erythematosus.
【作者单位】：吉林大学第一医院风湿免疫科;
【基金】：国家自然科学基金(No:3A515BF53428)
【分类号】：R593.24

【相似文献】