急性胰腺炎患者TNF-α基因多态性与病情严重程度及临床预后的相关性分析

发布时间：2018-05-19 21:02

  本文选题：胰腺炎 + 肿瘤坏死因子-α　； 参考：《重庆医学》2017年27期

【摘要】：目的探讨急性胰腺炎患者肿瘤坏死因子-α(TNF-α)基因多态性与患者病情严重程度及临床预后的相关性。方法选取山东省医学高等专科学校附属医院2015年6月至2016年6月确诊的325例急性胰腺炎患者,采集外周血检测TNF-α基因多态性,并用Balthazer CT严重指数(CTSI)评分和急性生理与慢性健康评分(APACHEⅡ)评价患者胰腺炎病情,根据患者APACHEⅡ评分进行分组,7分的患者为观察组,7分的患者为对照组,对比两组患者CTSI评分、TNF-α基因表达情况,并采用Logistic回归模型分析TNF-α基因多态性与急性胰腺炎预后的关系。结果观察组96例患者A/A基因型为68例,占70.1%,CTSI评分为(8.3±0.4)分,明显高于对照组患者,差异有统计学意义(P0.05),Logistic回归分析结果提示APACHEⅡ评分上升3分(P=0.016)、TNF-α基因rs1800629位点基因型为A/A(P=0.04)、CTSI评分上升2分(P=0.012)均是患者预后不良的独立危险因素。结论 TNF-α基因多态性及CTSI评分与急性胰腺炎病情严重程度及临床预后密切相关。
[Abstract]:Objective to investigate the relationship between tumor necrosis factor- 伪 (TNF- 伪) gene polymorphism and severity and clinical prognosis in patients with acute pancreatitis. Methods from June 2015 to June 2016, 325 patients with acute pancreatitis were selected from affiliated Hospital of Shandong Medical College, and peripheral blood samples were collected to detect the polymorphism of TNF- 伪 gene. The severity index of Balthazer CT and acute physiological and chronic health score (Apache 鈪，

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