CTLA4基因rs231775位点多态性与淮安地区汉族孕妇子痫前期遗传易感性相关性的研究

发布时间：2018-05-30 18:59

本文选题：子痫前期 + CTLA基因　；参考：《中国妇产科临床杂志》2017年03期

【摘要】：目的探讨CTLA4基因单核苷酸多态性位点rs231775与淮安地区汉族子痫前期发病风险的相关性。方法选择2008年6月至2014年4月在江苏省淮安市妇幼保健院产科住院分娩的子痫前期患者392例,选择同期正常妊娠孕妇317例作为对照组,采用基质辅助激光解吸附电离飞行时间质谱对CTLA4基因rs231775位点进行基因分型。结果子痫前期组CTLA4基因rs231775多态性位点GG、AG和AA基因型频率分别为53%,39%和8%,等位基因频率G,A分别为72%和28%;而在对照组中GG、AG和AA频率分别为45%,41%和14%,等位基因频率G,A分别为65%和35%。经卡方检验rs231775位点在两组的基因型和等位基因频率之间差异有统计学意义(P=0.025)。结论淮安地区的人群CTLA4基因rs231775位点的多态性与子痫前期有一定的关联。
[Abstract]:Objective to investigate the association between CTLA4 gene single nucleotide polymorphism (rs231775) and preeclampsia risk in the Han nationality in Huaian area. Methods 392 cases of preeclampsia were selected from June 2008 to April 2014 in Huaian Maternal and Child Health Hospital of Jiangsu Province. 317 normal pregnant women were selected as control group. The rs231775 loci of CTLA4 gene were genotyped by matrix assisted laser desorption ionization time of flight mass spectrometry. Results in preeclampsia group, the frequencies of GGG AG and AA genotype of CTLA4 gene rs231775 polymorphism were 53 39% and 8%, respectively, and the allelic frequencies were 72% and 28%, respectively, while in the control group, the frequencies of GGG AG and AA were 4541% and 14%, respectively, and the frequencies of GGG AG and AA were 65% and 35%, respectively. The difference of genotype and allele frequency of rs231775 locus between the two groups was statistically significant by chi-square test. Conclusion the polymorphism of rs231775 locus of CTLA4 gene is associated with preeclampsia in Huaian area.
【作者单位】：江苏大学医学院;扬州大学医学院附属淮安市妇幼保健院;
【基金】：江苏省淮安市科技支撑计划项目(HAS2010018,HAS2009003) 江苏省卫生厅妇幼保健重大科研项目(F201214) 淮安市科技创新载体平台建设计划项目(HAP201016)
【分类号】：R714.244

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