耳聋易感基因患儿人工耳蜗植入术后听觉言语能力评估

发布时间：2018-05-31 15:11

本文选题：耳聋 + 人工耳蜗　；参考：《中国听力语言康复科学杂志》2017年01期

【摘要】：目的探讨不同耳聋易感基因患儿人工耳蜗植入后不同阶段的康复效果和影响因素。方法回顾性分析192例人工耳蜗植入患者的临床资料,将患者分为GJB2基因突变组、SLC26A4基因突变组、线粒体12S rRNA基因突变组、常见耳聋基因检测阴性对照组,术后随访1年,采用汉语版人工耳蜗植入术后效果评估体系评估患者术后听觉能力、言语能力康复效果并进行分析。结果 MAIS得分,GJB2基因突变组的患儿术后评分优于对照组,其差异有统计学意义(P0.05),SLC26A4基因突变组随访结果统计学分析显示各项评估结果未显现出明显优势,线粒体12S rRNA基因突变组与对照组差异无统计学意义(P0.05)。通过CAP分级和SIR分级得分,4组间结果差异无统计学意义(P0.05)。各组患儿术前听觉言语能力得分与开机后术后3、6、9、12个月的听觉言语得分差异有统计学意义(P0.05)。结论不同耳聋易感基因的患儿人工耳蜗植入言语康复效果有差异,GJB2基因突变组各项随访结果显示出了较好的长期听觉。
[Abstract]:Objective to investigate the rehabilitation effect and influencing factors of cochlear implant in children with different deafness susceptibility genes. Methods the clinical data of 192 patients with cochlear implant were analyzed retrospectively. The patients were divided into three groups: GJB2 gene mutation group, mitochondrial 12s rRNA gene mutation group, and normal deafness gene negative control group. The patients were followed up for 1 year after operation. The effects of hearing and speech rehabilitation were evaluated and analyzed by the Chinese version of the evaluation system after cochlear implantation. Results the postoperative score of MAIS score group with GJB2 gene mutation was better than that of the control group, and the difference was statistically significant. There was no significant difference between the mitochondrial 12s rRNA gene mutation group and the control group (P 0.05). There was no significant difference in the scores of CAP and SIR among the four groups (P 0.05). The scores of auditory speech ability in each group were significantly different from those in 3 cases and 12 months after operation (P 0.05). Conclusion there are differences in speech rehabilitation of cochlear implants in children with different susceptibility genes to deafness. The follow-up results of GJB2 gene mutation group showed good long-term hearing.
【作者单位】：云南省昆明医科大学附属儿童医院;
【基金】：云南省卫生科技计划项目(2014NS054) 云南省科技厅昆明大学联合专项(2015FB090) 云南省教育厅科学研究基金项目(2015J050)
【分类号】：R764.9

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