CLOCK基因多态性与原发性男性不育相关性

发布时间：2018-06-04 04:29

本文选题：CLOCK + 原发性男性不育　；参考：《中国公共卫生》2017年01期

【摘要】：目的探讨生物钟基因(CLOCK)多态性与原发性男性不育之间的关系。方法以2005—2010年就诊于江苏省南京医科大学附属医院男性不育门诊的478例患者为病例组,同时选择就诊于其他门诊的有正常生育史的194名男性为对照组。取5 m L外周血检测血清睾酮(T)和促卵泡激素(FSH)水平,PCR检测CLOCK的rs1801260、rs3817444和rs3749474位点。结果在rs3749474位点携带TT基因型和TC+CC基因型的受试者中病例组血清FSH浓度明显高于对照组(P=0.0266),携带CC基因型的受试者中病例组血清T浓度明显高于对照组(P=0.0466);在rs1801260位点携带AA基因型的受试者中病例组血清FSH和T浓度均明显高于对照组(P分别为0.0016、0.0451);在rs3817444位点携带CC基因型和CA+AA基因型的受试者中病例组血清FSH浓度均明显高于对照组(P分别为0.0016、0.0430)。结论 CLOCK基因多态性与原发性男性不育存在关联。
[Abstract]:Objective to investigate the relationship between the polymorphism of clock gene and primary male sterility. Methods 478 male infertility patients from 2005 to 2010 in Nanjing Medical University affiliated Hospital of Jiangsu Province were selected as case group and 194 men with normal fertility history as control group. The levels of serum testosterone (T) and follicle stimulating hormone (FSH) were measured in 5 mL peripheral blood. The rs1801260 rs3817444 and rs3749474 loci of CLOCK were detected by PCR. Results the serum FSH concentration in the patients with TT genotype and TC CC genotype at rs3749474 locus was significantly higher than that in the control group (P 0.0266), the serum T concentration in the case group with CC genotype was significantly higher than that in the control group, and in the rs1801260 locus, the serum T concentration in the case group was significantly higher than that in the control group. The serum FSH and T concentrations in the patients with AA genotype were significantly higher than those in the control group (P = 0.0016, P = 0.0451, respectively), and the serum FSH concentrations in the patients with CC genotype and CA AA genotype at the rs3817444 locus were significantly higher than those in the control group (P = 0.0016, P = 0.0430, respectively). Conclusion CLOCK gene polymorphism is associated with primary male infertility.
【作者单位】：苏州大学公共卫生学院卫生毒理学教研室;
【基金】：国家自然科学基金(81473008) 苏州市科技项目(SYS201320)
【分类号】：R698.2

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