转录因子7类似物2基因的rs7903146位点多态性与新疆维吾尔族人群2型糖尿病的相关性研究

发布时间：2018-06-05 03:24

本文选题：单核苷酸多态性 + 转录因子类似物基因　；参考：《中国病理生理杂志》2017年08期

【摘要】：目的:探讨新疆地区维吾尔族人群转录因子7类似物2(transcription factor 7-like 2,TCF7L2)基因的rs7903146位点多态性与2型糖尿病的相关性。方法:采用病例-对照研究方法,以经确诊的935例2型糖尿病患者作为2型糖尿病组,选取971例健康体检者作为正常对照组。应用基质辅助激光解吸电离飞行时间质谱分析技术对TCF7L2基因多态性进行检测。结果:rs7903146位点基因型CC、CT和TT以及等位基因C和T在2型糖尿病组与正常对照组中分布的差异具有统计学意义(P0.05)。T等位基因携带者患2型糖尿病的风险是C等位基因携带者的1.190倍(OR=1.190,95%CI为1.034~1.371),CT基因型携带者患2型糖尿病的风险是CC基因型携带者的1.374倍(OR=1.374,95%CI为1.122~1.683),CT+TT基因型携带者患2型糖尿病的风险是CC基因型携带者的1.307倍(OR=1.307,95%CI为1.090~1.567)。在全体人群中,rs7903146位点的CT+TT基因型携带者的空腹血糖、肌酐和尿素氮水平显著高于CC基因型携带者,差异均具有统计学意义(P0.05)。结论:TCF7L2基因的rs7903146位点可能与新疆维吾尔族人群2型糖尿病的发生相关,T等位基因和CT基因型可能是2型糖尿病发生的危险因素。
[Abstract]:Objective: To investigate the correlation between the rs7903146 polymorphism of the transcription factor 7 analogue 2 (transcription factor 7-like 2, TCF7L2) gene and type 2 diabetes in the Uygur population in Xinjiang. Methods: a case control study was used in 935 patients with type 2 diabetes mellitus, which were diagnosed as type 2 diabetes, and selected 971 healthy persons. TCF7L2 gene polymorphism was detected by matrix assisted laser desorption ionization time of flight mass spectrometry analysis. Results: the differences in the distribution of genotype CC, CT, TT and C and T in type 2 diabetes group and normal control group of rs7903146 loci were of the type 2 (P0.05).T allele carriers. The risk of diabetes is 1.190 times as high as that of C allele carriers (OR=1.190,95%CI 1.034~1.371). The risk of type 2 diabetes in CT genotype carriers is 1.374 times the CC genotype (OR=1.374,95%CI 1.122~1.683), and the risk of type 2 diabetes in CT+TT genotype carriers is 1.307 times that of the CC genotype carriers (OR=1.307,95%CI is 1.09). 0~1.567). In the whole population, the fasting blood glucose, creatinine and urea nitrogen levels of the CT+TT genotype carriers of the rs7903146 locus were significantly higher than those of the CC genotype carriers. The difference was statistically significant (P0.05). Conclusion: the rs7903146 loci of the TCF7L2 gene may be associated with the occurrence of type 2 diabetes in the Uygur population of Xinjiang, T alleles and CT Genotype may be a risk factor for type 2 diabetes.
【作者单位】：新疆医科大学公共卫生学院;新疆医科大学第一附属医院代谢性疾病重点实验室;新疆医科大学第一附属医院内分泌科;
【基金】：国家重点基础研究发展计划(973计划)(No.2012CB722403)
【分类号】：R587.1

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