青藏高原藏族人群HLA-DRB1基因与包虫病遗传抗性关联研究

发布时间：2018-06-06 10:48

  本文选题：包虫病 + HLA-DRB　； 参考：《中国血吸虫病防治杂志》2017年05期

【摘要】：目的确定青藏高原地区藏族人群包虫病患者的人类白细胞抗原-DRB1(Human leukocyte antigen-DRB1,HLADRB1)等位基因中易感基因和抗性基因,为研究藏族人群包虫病的感染机制及遗传特点提供依据。方法本研究采用病例对照法。病例组选取青海省玉树和果洛藏族自治州的世居藏族囊型包虫病63例和泡型包虫病73例;对照组选取该地区无血缘关系的藏族健康人,共计60例。应用聚合酶链反应-直接碱基序列基因分型(PCR-SBT)技术,比较等位基因频率。结果泡型和囊型包虫病病例组HLA-DRB1*04等位基因频率均小于对照组(χ2=4.71、4.31,P均0.05)。结论HLA-DRB1*04等位基因与青藏高原藏族人群囊型和泡型包虫病相关联,对其感染有保护作用,是其抗性基因。
[Abstract]:Objective to identify susceptibility genes and resistance genes of human leukocyte antigen-DRB1 HLA-DRB1 alleles in patients with hydatid disease in Tibetan population in Qinghai-Tibet Plateau, and to provide evidence for studying the infection mechanism and genetic characteristics of hydatid disease in Tibetan population. Methods the case-control method was used in this study. 63 cases of Tibetan cystic echinococcosis and 73 cases of alveolar hydatidosis in Yushu and Guoluo Tibetan Autonomous Prefecture of Qinghai Province were selected in the case group, while 60 healthy Tibetan people in the control group were selected as control group. Polymerase chain reaction-direct base sequence genotyping (PCR-SBT) technique was used to compare allelic frequencies. Results the frequency of HLA-DRB1*04 alleles in patients with vesicular hydatid disease and cystic hydatid disease was lower than that in control group (蠂 ~ 2 = 4.71 ~ 4.31, P = 0.05). Conclusion HLA-DRB1*04 allele is associated with cystic and alveolar hydatid disease in Tibetan population of Qinghai-Xizang Plateau. It has protective effect on infection and is a resistant gene.
【作者单位】： 青海省人民医院;青海省地方病预防控制所;中国人民解放军第四医院;
【基金】：青海省科技厅资助项目(2015.ZJ.750)
【分类号】：R532.32
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本文编号：1986267