ACTN3基因R577X多态性与如皋地区汉族老年人群血脂水平的关联研究

发布时间：2018-06-08 03:10

本文选题：血脂异常 + ACTN基因　；参考：《复旦学报(医学版)》2017年04期

【摘要】：目的探讨中国汉族老年人群中ACTN3基因R577X多态性位点与血脂水平的关联。方法本研究基于如皋长寿及衰老队列研究(Rugao Longevity and Ageing Study,RuLAS)的衰老子队列人群。基因分型采用Taqman MGB方法。血脂检测指标为总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C),其切点依据NCEP ATPIII标准。通过协方差分析和Logistic回归分析,探究R577X多态性位点与血脂异常之间的关联。结果本研究共纳入1 618例样本(男性741例,女性877例)。协方差分析发现:在女性中RR、RX、XX基因型间TC和LDL-C水平差异均有统计学意义(TC:5.13、5.29、5.43 mmol/L,P=0.004;LDL-C:2.76、2.88、3.00mmol/L,P=0.004);在总人群中RR、RX、XX基因型间TG水平(1.34、1.43、1.37 mmol/L)差异有统计学意义(P=0.024)。Logistic回归分析发现,在总人群和女性中X等位基因的拷贝数增加与TC水平和LDL-C水平异常升高具有显著关联,总人群TC:OR=1.184,95%CI为1.030~1.361,P=0.018;总人群LDL-C:OR=1.332,95%CI为1.101~1.588,P=0.003;女性TC:OR=1.334,95%CI为1.102~1.616,P=0.003;女性LDL-C:OR=1.549,95%CI为1.208~1.986,P=0.001。调整其他协变量之后,以上关联仍然显著。结论在如皋地区汉族女性老年人群中,ACTN3基因R577X多态性与血浆TC、LDL-C水平相关。
[Abstract]:Objective to investigate the association between R577X polymorphism of ACTN3 gene and serum lipids in elderly Chinese Han population. Methods the study was based on Rugao Longevity and Ageing study (Rugao Longevity and Ageing study RuLAS). Taqman MGB method was used for genotyping. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), low density lipoprotein cholesterol (LDL-C) were measured. The association between R577X polymorphism locus and dyslipidemia was investigated by covariance analysis and logistic regression analysis. Results A total of 1,618 samples (741 males and 877 females) were included in this study. The results of covariance analysis showed that there were significant differences in TC and LDL-C levels among RRRXX XX genotypes in women. There were significant differences in TC and LDL-C levels among RRRXX XX genotypes. TC5.135.295.295.43 mmol / L P = 0.004 LDL-C: 2.76-2.883.00 mmol / L P 0.004; in the total population, there were significant differences in TG levels of 1.344 RXX XX genotypes and 1.37 mmol / L, respectively. Logistic regression analysis showed that there were significant differences in TC and LDL-C levels between RRRX and RXX XX genotypes. The increased copy number of X allele was significantly associated with the abnormal increase in TC and LDL-C levels in both the total population and the female population, TC: OR1.184 and 95CI was 1.0300.361P0.018; the total LDL-C: OR1.332C95CI was 1.1011.588P0.003; the female TCORO 1.33495CI was 1.1021.616P0.003; the female LDL-COR1.54995CI was 1.2081.986P0.001. After adjusting for the other covariables, the above correlation is still significant. Conclusion the R577X polymorphism of ACTN3 gene is associated with the plasma TCU LDL-C level in the elderly Han women in Rugao area.
【作者单位】：如皋市人民医院长寿研究所;复旦大学生命科学学院现代人类学教育部重点实验室;
【分类号】：R54

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