rs671和rs1801157基因多态性与云南汉族人群心肌梗死的易感性分析

发布时间：2018-06-09 21:32

本文选题：心肌梗死 + rs　；参考：《中国现代医学杂志》2017年30期

【摘要】：目的对云南高海拔地区汉族人群rs671和rs1801157单核苷酸多态性(SNP)进行分析,探讨其与心肌梗死(MI)易感性的关系。方法 Sequenom Mass Array系统基因分型方法对500例云南高海拔地区汉族MI患者和350例对照组患者rs671和rs1801157的基因多态性进行检测,结合患者CAD/MI主要独立危险因素(性别、年龄、高血压、糖尿病、脂质浓度、肥胖程度、烟酒史及家族史等),分析MI与SNP变化之间的潜在关联性。结果 rs671和rs1801157基因型在MI组和对照组中达到遗传平衡(P0.05)。MI组中rs671AA、AG及A等位基因频率与rs1801157的GG、GA及G等位基因均高于对照组,而rs671的GG基因型和rs1801157的AA频率、A等位基因低于对照组(P0.05)。加性模型下,rs671 A等位基因能增加MI的患病风险[^OR=2.57(95%CI:1.96,3.37)P0.05],而rs1801157基因型G等位基因能增加MI的患病风险[^OR=2.68(95%CI:1.84,3.15)P0.05];在显性模型下,rs671 A等位基因能增加MI的患病风险[^OR=3.69(95%CI:2.68,5.08)P0.05];在隐性模型下,rs671和rs1801157与MI无相关,^OR=3.86(95%CI:0.88,17.03,P=0.074)和2.06(95%CI:0.68,4.89,P=0.12)。在非饮酒患者中rs671 A等位基因能增加MI的患病风险[^OR=1.27(95%CI:1.05,2.93)P=0.032];在饮酒患者中rs671A等位基因不能增加MI的患病风险^OR=1.58(95%CI:0.84,1.87,P=0.36),在饮酒与否的患者中rs1801157均不增加MI的患病风险。结论 rs671和rs1801157位点的多态性变异与MI遗传易感性相关,rs671A和rs1801157等位基因能增加MI患者的患病风险。
[Abstract]:Objective to investigate the relationship between rs671 and rs1801157 single nucleotide polymorphisms (SNPs) and susceptibility to myocardial infarction (MI). Methods the gene polymorphisms of rs671 and rs1801157 in 500 patients with MI of Han nationality and 350 cases of control group were detected by Sequenom Mass Array genotyping. The main independent risk factors (sex, age, hypertension) of CAD / MI were analyzed. Diabetes, lipid concentration, obesity, alcohol and tobacco history, family history, etc., to analyze the potential association between MI and SNP changes. Results the frequencies of rs671AAAG and A alleles in MI group and control group were higher than those in control group, while the GG genotype and G allele of rs1801157 in rs671 group were lower than those in control group (P 0.05). The rs671A allele increased the risk of MI in the additive model [OR 2.5795 CI: 1.966 / 3.37], while the G allele of the rs1801157 genotype increased the risk of MI [OR2.6895CIV 1.84C: 3.15P05]; in the dominant model, the rs671A allele increased the risk of MI; and in the recessive model, the rs671 A allele increased the risk of MI. There is no correlation between rs1801157 and MI, but there is no correlation between rs1801157 and MI, and the two parts are: I: 0.88, 17.03, P0.074) and 2.06, 95, CI: 0.68, 4.89, P0. 12. The rs671 A allele increased the risk of MI in non-drinkers [1.2795]; in drinking patients, the rs671A allele did not increase the risk of MI. In drinking patients, the rs671A allele did not increase the risk of MI, nor did rs1801157 increase the risk of MI in those who drank or not. Conclusion Polymorphism of rs671 and rs1801157 loci is associated with genetic susceptibility to MI. The alleles of rs671A and rs1801157 can increase the risk of MI patients.
【作者单位】：昆明医科大学附属延安医院麻醉科;昆明医科大学附属延安医院心内科;
【基金】：云南省应用基础研究计划(昆医联合专项)(No:2013FZ288)
【分类号】：R542.22

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