转基因作物代谢组差异的协同性分析

发布时间：2018-06-15 17:29

本文选题：转基因作物 + 安全评价　；参考：《食品工业科技》2017年17期

【摘要】：转基因技术的应用十分广泛,尤其是用于获得具备优良性状的农作物新品种。但在转基因作物商业化推广的同时,农产品的安全问题一直备受关注。组学技术的不断发展,为转基因作物的安全评价提供了新方法。鉴于代谢组数据具有即时性和可获得性的特点,本文基于之前的研究,通过收集转基因作物代谢组方面文章的数据,对6种作物的野生型和转基因型样本的比较结果进行整合分析,通过显著性检验得到了8种代表性差异代谢物。代谢通路富集分析结果显示与这8种差异代谢物关联的蛋白质主要参与能量代谢过程,与已报道的单一物种转基因非预期效应的研究结果相同。该研究从代谢物和蛋白质两个方面说明转基因事件影响了这6种作物的能量代谢过程,并且该现象很可能普遍存在于多种转基因作物中。希望本研究结果可以为转基因农作物的安全评价提供参考。
[Abstract]:The application of transgenic technology is very extensive, especially for obtaining new varieties of crops with excellent characters. However, the safety of agricultural products has been paid much attention to at the same time of commercialization of genetically modified crops. The continuous development of technology has provided a new method for the safety evaluation of genetically modified crops. The characteristics of time and availability are based on the previous study. Through the collection of data on the metabolic groups of genetically modified crops, the comparison results of wild and genetically modified samples of 6 crops were integrated and analyzed, and 8 representative differential metabolites were obtained through the significance test. The results of metabolic pathway enrichment analysis showed that 8 The proteins associated with different metabolites are mainly involved in the energy metabolism process, which are the same as that of the unintended effects of the reported single species. This study shows that the two aspects of the metabolites and proteins indicate that the transgenic events affect the energy metabolism of the 6 crops, and the phenomenon is likely to exist in a variety of changes. It is hoped that the results of this study can provide a reference for the safety assessment of genetically modified crops.
【作者单位】：中国检验检疫科学研究院;广西出入境检验检疫局检验检疫技术中心;海南出入境检验检疫局检验检疫技术中心;
【基金】：转基因产品抽制样和精准检测技术(2018ZX08012-001) 广西区内主要农作物及其制品转基因精准检测技术研究与应用(2016GXCIQ003)
【分类号】：S188;TS201.6

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