载脂蛋白M基因rs707921位点多态性与冠心病易感性的关系

发布时间：2018-06-15 19:47

本文选题：载脂蛋白M + 冠心病　；参考：《中国动脉硬化杂志》2017年07期

【摘要】：目的检测载脂蛋白M(ApoM)基因rs707921位点的基因多态性,探讨其与冠心病(CHD)的相关性。方法采用单荧光标记探针技术检测111例CHD患者及248例对照组的ApoM rs707921位点单核苷酸多态性,分析其基因型和等位基因频率的分布情况。结果 ApoM rs707921位点3种基因型(AA型、AC型和CC型)在CHD组中分布频率为1.8%、13.5%和84.7%,在对照组中分布频率为2.0%、25.4%和72.6%,两组差异有统计学意义(P=0.039);ApoM rs707921位点A、C等位基因的频率在CHD组和对照组中分布频率分别为8.6%、91.4%和14.7%、85.3%,两组比较差异有统计学意义(P=0.023)。CHD组中AC+AA基因型者甘油三酯水平显著低于CC基因型者(P=0.043)。CHD组rs707921位点多态性不同基因型间冠状动脉病变严重程度差异无统计学意义(P0.05)。结论ApoM基因rs707921位点A等位基因可能降低CHD的发病风险,但与CHD的严重程度无关。
[Abstract]:Objective to detect the rs707921 polymorphism of apolipoprotein (ApoM) gene and its association with coronary heart disease (CHD). Methods single nucleotide polymorphisms at Apo M rs707921 locus were detected by single fluorescent probe technique in 111 patients with CHD and 248 controls, and the distribution of genotypes and alleles were analyzed. Results the distribution frequency of ApoM rs707921 locus was 1.813.5% and 84.7% in ApoM rs707921 group, and 25.4% and 72.6% in control group. The difference between the two groups was statistically significant. The distribution of triglyceride in AC AA genotype group was significantly lower than that in CC genotype group (P < 0.023). The rs707921 locus polymorphism in CC genotype group was significantly lower than that in CC genotype group. There was no significant difference in severity between the two groups (P 0.05). Conclusion A allele at rs707921 locus of ApoM gene may decrease the risk of CHD, but it is not related to the severity of CHD.
【作者单位】：苏州大学附属第三医院心内科;苏州大学附属第三医院综合实验室;
【基金】：常州市科技局科技支撑(社会发展)项目(20135063)
【分类号】：R541.4

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