凝血因子Ⅻ基因多态性与急性心肌梗死的关联性研究

发布时间：2018-07-03 07:18

  本文选题：心肌梗死 + 凝血因子Ⅻ　； 参考：《浙江医学》2016年23期

【摘要】：目的分析急性心肌梗死(AMI)患者凝血因子Ⅻ(FⅫ)基因多态性和急性发作时血浆凝血因子Ⅻ活性(FⅫ:C)的变化及意义。方法收集97例AMI患者治疗前及76例对照血液标本,采用直接测序法检测FⅫ第46位基因多态性和一期凝固法检测血浆FⅫ:C,并进行比较分析。结果 FⅫ基因C46T多态位点CC、CT、TT 3种基因型以及C、T等位基因频率在AMI组与对照组中的分布均无统计学差异(均P0.05)。CC、CT和TT 3种基因型分别对应的血浆FⅫ:C水平有统计学差异(P0.01),以CC组活性最高,TT组活性最低。AMI组血浆FⅫ:C显著低于对照组(P0.01)。结论 FⅫC46T基因多态性与AMI无关联,AMI发病时血浆FⅫ:C显著降低,FⅫ参与血栓形成。
[Abstract]:Objective to analyze the variation and significance of the gene polymorphisms of clotting factor (F) and the activity of plasma coagulation factor (F?) in patients with acute myocardial infarction (AMI) during acute exacerbation of acute myocardial infarction (AMI). Methods 97 patients with AMI and 76 control blood samples were collected. The 46th position polymorphism of F _ (XII) gene was detected by direct sequencing method, and the plasma F _ (鈪，

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